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Submucosal neoplasms of the laryngeal introitus

  • A D Friedman (a1), J A Burns (a1), M J Lutch (a2) and S M Zeitels (a1)
  • DOI:
  • Published online: 25 May 2012

The differential diagnosis of endolaryngeal mesenchymal neoplasms includes a wide spectrum of benign and malignant pathologies, which have been rarely photo-documented and assessed as a group.


Non-epithelial neoplasms of the endolarynx seen at our centre from 2002 to 2011 (n = 38; 36 treated at our institution) were retrospectively reviewed, with attention to clinical presentation, radiographic imaging, operative management, histology, and pre- and post-operative endoscopy. Submucosal squamous cell carcinomas, mucosal cysts, amyloid and Teflon granulomas were excluded.


Twenty-three of a total of 36 patients underwent definitive endoscopic surgical treatment. Supraglottic pathologies included lymphoma, lipoma, neuroendocrine carcinoma, lymphangioma, oncocytoma, haemangioma, synovial cell sarcoma and benign spindle cell neoplasm. Transglottic pathologies included synovial cell sarcoma and granular cell tumour. Glottic pathologies included granular cell tumour, osteoma, rhabdomyoma, rhabdomycosarcoma and myofibroblastic sarcoma. Subglottic pathologies included chondrosarcoma, neurofibroma, adenoid cystic carcinoma and vascular malformation.


The site of origin, degree of malignant behaviour and sensitivity to adjuvant treatment determined the course of surgical management, i.e. endolaryngeal versus transcervical, and limited removal versus wider resection.

Corresponding author
Address for correspondence: Dr Aaron D Friedman, Massachusetts General Hospital, Center for Laryngeal Surgery and Voice Rehabilitation, One Bowdoin Square, 11th Floor, Boston, MA 02114, USA Fax: +1 617 726 0222 E-mail:
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Presented as a poster at the Eastern Section Meeting of the Triological Society, 23–25 January 2009, Boston, Massachusetts, USA

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4RT Sataloff , JC Ressue , M Portell , RM Harris , R Ossoff , AL Merati Granular cell tumors of the larynx. J Voice 2000;14:119–34

6J Ebmeyer , U Reineke , HB Gehl , U Hamberger , R Mlynski , M Essing Schwannoma of the larynx. Head Neck Oncol 2009;1:24

10SM Zeitels , LM Akst , JA Bums , RE Hillman , MS Broadhurst , RR Anderson . Pulsed angiolytic laser treatment of ectasias and varices in singers. Ann Otol Rhinol Laryngol 2006;115:571–80

16WJ Harb , MA Luna , SR Patel , MT Ballo , DB Roberts , EM Sturgis . Survival in patients with synovial sarcoma of the head and neck: association with tumor location, size, and extension. Head Neck 2007;29:731–40

17HJ Quinn Jr. Synovial sarcoma of the larynx treated by partial laryngectomy. Laryngoscope 1984;94:1158–61

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The Journal of Laryngology & Otology
  • ISSN: 0022-2151
  • EISSN: 1748-5460
  • URL: /core/journals/journal-of-laryngology-and-otology
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