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Transtympanic dexamethasone application in Ménière's disease: an alternative treatment for intractable vertigo

  • Levent Sennaroğlu (a1), Farzin Mottaghian Dini (a1), Gonca Sennaroğlu (a2), Bulent Gursel (a1) and Soner Ozkan (a2)...
Abstract

The aetiology of Ménière's disease still remains unknown and its therapy is therefore empirical. As a result of immunological abnormalities demonstrated, steroids are commonly used in Ménière's disease. The place of topical steroids is still controversial. In this investigation topical dexamethasone is applied for three months through a ventilation tube in patients with intractable vertigo. The results showed that this treatment controls vertigo in 72 per cent of cases. No patient was worse than before treatment. Only in 17 per cent of the patients was there an increase in hearing level. When compared to the reports which used only tympanostomy tubes, this procedure seems to have a placebo effect with minimal harmful effects. It appears that transtympanic dexamethasone application is a good alternative to vestibular nerve section. Topical treatment may be sufficient in most patients. Systemic treatment may be used in patients where topical treatment fails.

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Corresponding author
Address for correspondence: Levent Sennaroğlu, M.D., Büklüm Sokak 45/16, Kavaklidere, Ankara 06660, Turkey. Fax: 90-312-3113500
References
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Brookes, G. B. (1986) Circulating immune complexes in Ménière's disease. Archives of Otolaryngology – Head and Neck Surgery 112 536540.
Danckwardt-Lilliestrom, N., Friberg, U., Kinnetors, A. (1997) Endolymphatic sacitis in a case of active Ménière's disease. A TEM histopathological investigation. Annals of Otology, Rhinology and Laryngology 106(3) 190198.
Gutierrez, F., Moreno, P. M., Sainz, M. (1994) Relationship between immune complex and total hemolytic complement in endolymphatic hydrops. Laryngoscope 104 14951498.
Itoh, A., Sakata, E. (1991) Treatment of vestibular disorders. Acta Otolaryngologica (Stockh) 481 617623.
Kimura, R. S., Hutta, J. (1997) Inhibition of experimentally induced endolymphatic hydrops by middle ear ventilation. European Archives of Otorhinolaryngology 254 213218.
Lohuis, P. J., ten Cate, W. J., Patterson, K. E. (1990) Modulation of rat stria vascularis in the absence of circulating adrenocorticosteroids. Acta Otolaryngologica (Stockh) 110 348356.
Montandon, P., Guillemin, P., Hausler, R. (1988) Prevention of vertigo in Ménière's syndrome by means of transtympanic ventilation tubes. ORL 50 377381.
Nadel, D. M. (1996) The use of systemic steroids in otolaryngology. Ear, Nose and Throat Journal 75 502516.
Pearson, B., Brackmann, D. E. (1985) Committee on hearing and equilibrium guidelines for reporting treatment results in Ménière's disease. Otolaryngology – Head and Neck Surgery 96 8395.
Rarey, K. E., Lohuis, P. J. F. M., ten Cate, W. J. F. (1991) Response of stria vascularis to corticosteroids. Laryngoscope 101 10811084.
Shea, J. J. (1993) Classification of Ménière's disease. American Journal of Otology 4 224229.
Shea, J. J., Ge, X. (1996) Dexamethasone perfusion of the labyrinth plus intravenous dexamethasone for Ménière's disease. Otolaryngologic Clinics of North America 29 353358.
Silverstein, H., Choo, D., Rosenberg, S., Kuhn, J. (1996) Intratympanic steroid treatment of inner ear disease and tinnitus (Preliminary report). Ear, Nose and Throat Journal 75 468488.
Suzuki, M., Kitahara, M. (1992) Immunologic abnormality in Ménière's disease. Otolaryngology – Head and Neck Surgery 107 5762.
Tumarkin, A. (1966) Thoughts on the treatment of labyrinthopathy. Journal of Laryngology and Otology 80 10411053.
Yamanobe, S., Harris, J. P. (1993) Inner ear specific antibodies. Laryngoscope 103 319325.
Yoo, T. J. (1984) Etiopathogenesis of Ménière's disease. A hypothesis. Annals of Otology, Rhinology and Laryngology (Suppl 113) 93 612.
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The Journal of Laryngology & Otology
  • ISSN: 0022-2151
  • EISSN: 1748-5460
  • URL: /core/journals/journal-of-laryngology-and-otology
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