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Treatment of head and neck cancer with photodynamic therapy: results after one year

Published online by Cambridge University Press:  29 June 2007

M. G. Dtlkes ,
M. L. DeJode ,
Q. Gardiner ,
G. S. Kenyon  and
P. McKelvie
M. G. Dtlkes*
Affiliation:
Department of Otolaryngology and the Surgical Unit, The Royal London Hospital, Whitechapel, London El 1BB
M. L. DeJode
Affiliation:
Department of Otolaryngology and the Surgical Unit, The Royal London Hospital, Whitechapel, London El 1BB
Q. Gardiner
Affiliation:
Department of Otolaryngology and the Surgical Unit, The Royal London Hospital, Whitechapel, London El 1BB
G. S. Kenyon
Affiliation:
Department of Otolaryngology and the Surgical Unit, The Royal London Hospital, Whitechapel, London El 1BB
P. McKelvie
Affiliation:
Department of Otolaryngology and the Surgical Unit, The Royal London Hospital, Whitechapel, London El 1BB
*
Mr M. G. Dilkes, F.R.C.S.(Ed.), F.R.C.S., 64, Wembley Park Drive, Wembley Park, Middlesex HA9 8HB.
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Abstract

Photodynamic therapy (PDT) is a new and promising treatment modality for the treatment of malignant disease. This paper reports the preliminary experience of our group in the use of this therapy for the treatment of tumours arising in the head and neck. The majority of treatments in these cases have used a second generation systemic photosensitizer, meta-tetrahydroxyphenylchlorin (m-THPC). Two other cases were treated with either Photofrin 2 (a first generation systemic sensitizer) or with the topical photosensitizer, delta-aminolaevulinic acid (δ-ALA).

The initial results have been encouraging with good clinical responses evident in patients presenting with a variety of differing tumour types. We feel there is now sufficient evidence of the efficacy of this treatment to warrant a multicentre prospective study into the treatment of early head and neck cancer with PDT.

Keywords

Head and neck neoplasmsPhotochemotherapy
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 109 , Issue 11 , November 1995 , pp. 1072 - 1076
Copyright
Copyright © JLO (1984) Limited 1995

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References

Berenbaum, M. C., Akande, S. L., Bonnet, R., Kaur, H.. Ioannou, S., White, R. D., Winfield, U.-J. (1989) Meso-tetra (hydroxyphenyl) porphyrins, a new class of potent tumour photosensitizers with favourable selectivity. British Journal of Cancer 54: 717–725.CrossRefGoogle Scholar
Bonnet, R., Berenbaum, M. C. (1989) Porphyrins as photo- sensitizers. In Photosensitizing Compounds: their Chemistry, Biology and Clinical use. (CIBA Foundation Symposium 146). Wiley, Chichester, pp 40–59.Google Scholar
Chevretton, E. B. (1993) M.S. Thesis, London University.Google Scholar
Davis, R. K., Smith, L. F., Thurgood, R. F., Kereszti, Z., Straight, R. C. (1990) Intraoperative phototherapy (PDT) and surgical resection in a mouse neuroblastoma model. Lasers in Surgery and Medicine 10: 275–279.Google Scholar
Dilkes, M. G. (1995) M.S. Thesis, London University in press.Google Scholar
Dougherty, T. J. (1989) Photodynamic therapy — new approaches. Seminars in Surgical Oncology 5: 6–16.CrossRefGoogle ScholarPubMed
Gluckman, J. L. (1991) Hematoporphyrin photodynamic therapy: is there truly a future in head and neck oncology? Reflections on a 5-year experience. Laryngoscope 101: 36–41.CrossRefGoogle Scholar
Johansen, L. V., Overgaard, J., Overgaard, M., Birkler, N.. Fisker, A. (1990) Squamous cell carcinoma of the oropharynx: an analysis of 213 consecutive patients scheduled for primary radiotherapy. Laryngoscope 100: 985–990.CrossRefGoogle ScholarPubMed
Kelly, J. F., Snell, M. E.(1976) Hematoporphyrin derivative: a possible aid in the diagnosis and therapy of carcinoma of the bladder. Journal of Urology 115: 150–151.Google Scholar
Lipson, R., Baldes, E., Olsen, A. (1961) The use of a derivative of hematoporphyrin in tumour detection. Journal of the National Cancer Institute 26: 1–8.Google Scholar
Monnier, Ph., Savary, M., Fontolliet, Ch., Wagnieres, G.. Chatelain, A., Cornaz, P., Depeursinghe, Ch., Van den Burgh, H. (1990) Photodetection and photodynamic therapy of 'early SCC of the pharynx, oesophagus and tracheobronchial tree'. Lasers in Medical Science 5: 149–169.Google Scholar
Ris, H. B., Altermatt, H. J., Stewart, C. M., Schaffner, T., Wang, Q., Lim, C. K., Bonnet, R., Aldhaus, U. (1993) Photodynamic therapy with m-tetrahydroxyphenylchlorin in vivo: optimization of the therapeutic index. International Journal of Cancer 55: 245–249.CrossRefGoogle ScholarPubMed
Weishaupt, K. R., Gomer, C. J., Dougherty, T. J. (1976) Identification of singlet oxygen as the cytotoxic agent in photoinactivation of a murine tumour. Cancer Research 36: 2326–2329.Google Scholar