Hostname: page-component-76fb5796d-r6qrq Total loading time: 0 Render date: 2024-04-26T03:55:28.545Z Has data issue: false hasContentIssue false
  • English
  • Français

The treatment of head and neck carcinoma with Adriamycin and Belomycin using adjuvant hyperthermia

Published online by Cambridge University Press:  29 June 2007

H. D. Fairman
H. D. Fairman
Affiliation:
Truro
Get access Rights & Permissions [Opens in a new window]

Summary

Twenty-two cases of carcinoma of the head and neck (predominantly squamous), in a veriety of sites, were treated with an oncolytic regime of Adriamycin and Bleomycin. Adjuvant hyperthermia was given to all cases; differing techniques of drug administration were used, depending on whether a case had received previous irradiation. Twenty-one cases showed response to treatment. Post-irradiation cases fared less well than those in which radiotherapy was synchronised with treatment.

Type
Research Article
Information
The Journal of Laryngology & Otology , Volume 96 , Issue 3 , March 1982 , pp. 251 - 264
Copyright
Copyright © JLO (1984) Limited 1982

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Berdal, P., Ekroll, T., Iversen, O. H. and Weyde, R. (1972) Treatment of Squamous Cell Carcinomas in Head & Neck with Bleomycin and with Bleomycin and X-ray. Tidsk. Norske Laeg., 92: 2247–2250.Google Scholar
Berdal, P., Ekroll, T., Iversen, O. H. and Weyde, R. (1974) Radiotherapy in the Treatment of Squamous Cell Carcinoma of the Head & Neck—A Clinical and Histological Study. Bleomycin Symposium Leiden 23rd November, 53–61.Google Scholar
Brenner, H. J. and Yerushalmi, A. (1975) Combined Local Hyperthermia and X-Irradiation in the Treatment of Metastatic Tumours. British Journal of Cancer, 33: 91.CrossRefGoogle Scholar
Danopoulos, E. D. and Danopoulo, I. E. (1974) Urea Treatment of Skin Malignancies. Lancet No. 7848, 115–118.CrossRefGoogle ScholarPubMed
Dickson, J. A. and Shah, S. A. (1977) Technology for the Hyperthermic Treatment of Large Solid Tumours at 50°C. Clinical Oncology, 3: 301–318.Google Scholar
Field, S. B. and Bleehan, N. M. (1979) Hyperthermia in the Treatment of Cancer. Cancer Treatment Reviews, 6: 63–94.CrossRefGoogle ScholarPubMed
Frei, E. (1974) Combination Chemotherapy, Proceedings of the Royal Society of Medicine, 67: 425–432.CrossRefGoogle ScholarPubMed
Hahn, G. M., Braun, J. and Har-kedar, I. (1975) Thermochemotherapy; Synergism between Hyperthermia (42–43°C) and Adriamycin (or Bleomycin) in Mammalian Cell Inactivations.CrossRefGoogle Scholar
Hanle, K. J. and Dethlefsen, L. A. (1978) Heat Fractionation and Thermotolerance; A Review. Cancer Research, 38: 1843–1851.Google Scholar
Kim, J. H., Hahn, E. N. and Benjamin, F. J. (1979) Treatment of Superficial Cancers by Combination Hyperthermia and Radiation Therapy. Clinical Bulletin, 9: 13–16.Google ScholarPubMed
Leveen, H. H., Wapnick, S., Piccone, V., Falk, G. and Ahmed, N. (1976) Tumour Eradication by Radiofrequency Therapy. Journal of the American Medical Association, 235: 2198–2200.CrossRefGoogle ScholarPubMed
O'connor, A. D., Clifford, P., Durden smith, D. J., Edwards, W., Hollis, B. A. and Dalley, V. M. (1977) Synchronous VBM and Radiotherapy in the Treatment of Squamous Cell Carcinoma of the Head & Neck. Clinical Otolaryngology, 1: 347–357.CrossRefGoogle Scholar
Overgaard, J. (1976) Combined Adriamycin and Hyperthermia Treatment of Murine Mammary In Vivo. Cancer Research, 36: 3077–3080.Google ScholarPubMed
Rygard, J. and Hansen, S. H. (1974) Tumour Effect and Complications of Bleomycin alone as an Adjunct to Radiotherapy in the Treatment of Squamous Cell Carcinoma of the Head & Neck. Bleomycin Symposium, Leiden, 23rdNovember, 39–52.Google Scholar
Yatvin, M. B., Clifton, K. H. and Dennis, W. H. (1979) Hyperthermia and Local Anaesthetics. Potentiation of Survival in Tumour Bearing Mice. Science, 205: 195.CrossRefGoogle Scholar