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Clinical Studies with LSD-25 and Two Substances Related to Serotonin

Published online by Cambridge University Press:  08 February 2018

Gerald D. Klee ,
Joseph Bertino ,
Enoch Callaway  and
Walter Weintraub
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Extract

In 1953, Twarog and Page (1) demonstrated that 5-hydroxytryptamine (serotonin) is present in relatively high concentrations in the brain. At about the same time Gaddum (2) and Woolley and Shaw (3) observed that LSD is a highly potent serotonin antagonist in such tissues as rat uterus and hypothesized that the hallucinogenic effect of LSD might be due to interference in the action of serotonin.

Type
Original Articles
Information
Journal of Mental Science , Volume 106 , Issue 442 , January 1960 , pp. 301 - 308
Copyright
Copyright © Royal College of Psychiatrists, 1960 

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References

References

1. Twarog, B. M., and Page, I. H., Am. J. Physiol., 1953, 175, 157.Google Scholar
2. Gaddum, J. H., J. Physiol., 1953, 121, 15.Google Scholar
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References and Notes

1. Udenfriend, S., Bogdanski, D. F., and Weissbach, H., Fed. Proc., 1956, 15, 493.Google Scholar
2. Idem , Weissbach, H., and Bogdanski, D. F., J. Biol. Chem., 1957, 224, 803.Google Scholar
3. Davidson, J., Sjoerdsma, A., Loomis, L. N., and Udenfriend, S., J. Clin. Inv. 1957, 36, 1594.Google Scholar
4. Bessman, , Merlis, and Borges, , Proceedings of the Society for Experimental Biology and Medicine, 1957, 95, 502.Google Scholar
5. Gaddum, J. H., Am. J. Phys., 1953, 121, 15.Google Scholar
6. Obtained from the California Biochemical Corporation. Sterilization was accomplished by heating the solid at a temperature of 100† C. for 60 minutes. Just prior to use, the material was dissolved in 200 cc. Saline. (Bessman, S.—personal communication.)Google Scholar
7. Udenfriend, S., Weissbach, H., and Clark, C., J. Biol. Chem., 1955, 215, 337.Google Scholar
8. Idem , Titus, E., and Weissbach, H., J. Biol. Chem., 1955, 216, 499.Google Scholar
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