The hypnotic powers of apomorphine have been overshadowed by its action as an emetic, but that it possesses sedative and hypnotic powers appears from recent investigations. In 1901 Merck reported the results obtained by Ch. I. Douglas with small doses, insufficient to nauseate. The mean hypnotic dose was about 2 m.g. (grain) i. e., about one third of the emetic dose. Sleep was said to follow within five to twenty-five minutes, and to last one to two hours. Because of the short duration of the sleep it was advised to associate some mild hypnotic with the apomorphine. Further reports come now from Rabon, Coleman and Polk, and Faucher, who, working with doses ranging between and grain, find the drug of great use as a sedative and soporific in states of violent excitement and restlessness. The doses are invariably given hypodermically, and vomiting or nausea is generally produced. Coleman and Polk have used apomorphine in the excitement of alcoholics (grain) with much success; Faucher in hysteria, hystero-epilepsy, and epilepsy pure and simple. In hysteria the mental impression caused by the hypodermic needle is probably of value in addition to the undoubted depression caused by the vomiting.
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