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A Contribution to the Morbid Anatomy and Pathology of the Neuro-Muscular Changes in General Paralysis of the Insane

  • Alfred W. Campbell (a1)

It is only within the last two or three years that alienists have learnt to recognize the importance of the existence in cases of progressive paralysis of the insane of certain extremely interesting neuro-muscular anatomical alterations. Too long was the teaching of Lockhart Clarke,1 Tigges,2 Westphal,3 Magnan,4 Voisin,5 Mendel,6 etc., that the cerebrospinal changes represented the sole anatomical substratum of the clinical features in this disease, regarded as infallible, and it is pleasing to think that our erroneous conceptions have been removed by the energetic researches and discoveries of another generation, including among their number Déjerine,7 Lubimoff,8 Mierzejewski,9 Bianchi,10 Fürst-

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1 “On the Morbid Anatomy of the Nervous Centres in General Paralysis of the Insane.” “Lancet,” Sept., 1866.
2 “Pathologische, anatomische und physiologische Untersuchungen über Dementia progressiva paralytica.” “Allg. Zeitschr. f. Psychiatrie,” Bd. xx.
3 (a.) “Über Erkrankungen des Rückenmarkes bei der allgemeinen progressiven Paralyse der Irren.” “Virchow's Archiv.,” 1867.
(b.) “Ueber den gegenwärtigen Standpunkt der Kenntnisse von der Allgemeinen progressiven Paralyse der Irren.” “Arch, für Psych, und Nervenkrank.,” Berlin, 1868.
4 “De la lésion anatomique de la paralysie générale.” Thése de Paris, 1866.
5 “Traité de la Paralysie générale des Aliénés.” Paris, 1879.
6 “Die progressive Paralyse der Irren.” 1880.
7 “Archiv. de Physiologie,” p. 317. 1876.
8 “Virch. Archiv.,” Bd. 57, p. 371.
9 “Archiv. de Physiologie,” 1875, p. 195.
10 “La base anatomica della paralisi progressiva.” “Ricerche istologische.” 1887.
11 “Zur Path. und Path. Anatom. der prog. Paral. imbesondere über die Veränderungen des Bückenmarkes und der peripheren Nerven.” “Arch. f. Psych.,” Berlin, 1892, 24.
12 “West Riding Asylum Reports,” Vol. 5., 1875.
13 “Annali di Neurologia,” 1891, pp. 115200.
14 “Brain,” 1892, p. 241.
* The entire material, both clinical and pathological, for my observations has been afforded by the County Asylum, Rainhill.
15 “Von Kahlden. Technik der histologischen Untersuchung pathologisch-anatomischer Präparate.” Jena, 1892, p. 97.
16 “Von Kahlden.,” p. 90.
* A brief account of this case was given by Dr. Wiglesworth in this Journal in his paper on “General Paralysis about the Period of Puberty,” July, 1893.
17 “Contribution à Pétude de la névrite alcoolique.” “Arch, de phys. norm. et path.,” 1887.
18 “Alcoholic Paralysis of the Phrenic, Pneumogastric, and other Nerves.” “Transactions of the Path. Soc. London,” 1888.
19 “Ein Beitrag zur path. Anatomie der sog. Polyneuritis alcoholica,” “Zeitschrift für Heilkunde,” Prag., 1892.
20 (a) “Journal of Mental Science,” Apr., 1872, p. 31.
20 (b) “On General Paralysis of the Insane,” 2nd Ed., p. 186.
21 “Ein Fall von Vaguserkrankung bei progressiver Paralyse.” “Allg. Zeitschrift für Psychiatrie, Berlin,” 1888, 44, p. 495.
22 “La pulmonite dei paralytici e la degenerazione dei nervi vaghi.” La Psichiatria, 1889.
23 “Les Nerfs vasomoteurs,” 5., ii.
24 Loc. cit. (b), p. 296. This writer found tubercle in an average of 25 per cent.
25 “The Pulmonary Pathology of General Paralysis.” “Brain,” 1883-84, 6., pp. 317341.
26 “Tabes mit Zwerchfellslähmung.” “Berliner klinische Wochenschrift,” No. xvi., 1893.
* Sc called by Vanlair, Déjerine, Gombault, etc.; described as “degenerative atrophy,” or simple degeneration of the nerve fibres, by others.
27 “Beitrag zur Kenntniss der multiplen degeneratiren Neuritis.” “Zeitsch. für Klin. Med.,” 1891.
28 “Neuritis fascians. Ein Beitrag zur Lehre von der Alcoholneuritis.” “Virchow Archiv.,” 112 B., 1888.
29 Note on optic nerve atrophy preceding the mental symptoms of General Paralysis of the Insane. “Journal Ment. Sci.,” 1889, pp. 389391.
30 “Text-Book of Mental Diseases,” London, 1889, p. 283.
31 “Ein Fall von Alcoholneuritis mit hervorragender Betheiligung des Muskel apparates.” “Charitè Annalen,” 1889.
32 “Lésions des poumons du cœur, du foie et des reins dans la paralysie générate.” “Archives de méd. expérimentale,” July 1, 1892.
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A Contribution to the Morbid Anatomy and Pathology of the Neuro-Muscular Changes in General Paralysis of the Insane

  • Alfred W. Campbell (a1)
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