In a paper I had the honour of reading before you last December I called attention to the high percentage of patients who died of general paralysis of the insane showing post-mortem signs of disease of the kidney. The task I then set myself was to find out, if possible, what was the pathological relation between the two. The arteries seemed to me to be the only connecting link. I then proceeded to point out that a diseased condition of the cerebral arteries occurred in those dying with granular kidneys, very similar to, if not identical with, what is found in those dying of general paralysis of the insane. And, finally, I called attention to three possible explanations of this apparent relationship.
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