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The Presence in Blood Sera of Substances which have an Activating or Inhibitory Effect on the Hæmolytic Properties of Cobra Venom

  • Charles James Ross (a1)
Extract

Medical science on the experimental side has been productive of no more interesting or fruitful results than those which have appeared in connection with the study of hæmolysis. The groundwork of this subject was laid by Bordet (1) in 1900 by the discovery of the fact that an immune serum contains a thermostable substance (immune body), which, in the presence of the original immunising agent (blood-corpuscles or bacteria), is capable of absorbing complement; that is to say, a hæmolytic or bacteriolytic serum heated to 57° C. for an hour will lose its power of lysing the homologous blood or organisms, but it will retain thermostable substances whose activity can be restored by the addition of fresh non-immune serum.

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(1) Bordet, J., “Les serums hemolytiques,” Ann. de l'Inst. Pasteur, Paris, 1900, tome xiv, p. 257.
(2) Muir, and Browning, , Journ. Path. and Bact., Cambridge, 1908, Vol. xiii, p. 76.
(3) Gengou, , “Sur les sensibilatrices des serums actifs,” Ann. de l'Inst. Pasteur, Paris, 1902, tome xvi, p. 734.
(4) Moreschi, , “Zur Lehre von den Antekomplementen,” Berl. klin. Wochenschr., 1905, No. 37, S. 1181.
(5) Neisser, and Sachs, , “Ein Verfahren zum forensischen Nachweis der Herkunft des Blutes,” Berl. klin. Wochenschr., 1905, No. 44, S. 1388.
(6) Muir, , Studies on Immunity, 1909, p. 133.
(7) Wassermann, and Bruck, , “Experimentelle Studien über die Wirkung von Tuberkel-bacillen-preparaten auf den tuberkelösen erkrankten Organismus,” Deutsch. med. Wochenschr., 1906, No. 12, S. 450.
(8) Wassermann, , Neisser, , and Bruck, , Deutsch. med. Wochenschr., 1906, No. 19, S. 745.
(9) Marie, and Levaditi, , “Les anticorps syphilitiques,” Ann. de l'Inst. Pasteur, Paris, 1907, tome xxi, p. 138.
(10) Sachs, and Altmann, , Berl. klin. Wochenschr., 1908, Nos. 10 and 14, S.S. 494, 699.
(11) Browning, and MacKenzie, , Journ. of Path, and Bact., Vol. xiii, p. 325.
(12) Flexner, and Noguchi, , Journ. of Exper. Med., Vol. vi, No. 3, 1902.
(13) Kyes, , “Ehrlich,” Studies in Immunity, 1910, p. 291.
(14) Much, and Holzmann, , “Eine Reaktion im Blute von Geisteskranken,” Münch, med. Wochenschr., 1909, No. 20, S. 1001.
(15) Kyes, and Sachs, , “Ehrlich,” Studies in Immunity, 1910, p. 443.
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The Presence in Blood Sera of Substances which have an Activating or Inhibitory Effect on the Hæmolytic Properties of Cobra Venom

  • Charles James Ross (a1)
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