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Regarding the Treatment of General Paralysis

  • G. H. Monrad-Krohn (a1)

When Noguchi found spirochaetes in the brain of general paralytics some years ago it seemed as if we were entering into a new era, not only in the pathological conception of the so-called “parasyphilitic” or “metasyphilitic” affections, but also in their treatment. In this latter respect most of us have hitherto been somewhat disappointed, and it may therefore be advisable to take up the rationale of the treatment for revision.

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(1) If the spirochæte has a life-cycle (as McDonagh will have it), it would not be surprising to find certain phases of the life-cycle immune to the usual anti-syphilitic remedies.—(2) With regard to the modifications they propose, I shall just mention that after injection of the full dose of 0.9 neosalvarsan arsenic can be found in the blood, and anyway, it is on account of such concentration in the blood after intravenous injections that it acts on syphilitic lesions in other organs. Why should a stronger concentration be needed in the brain?

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The British Journal of Psychiatry
  • ISSN: -
  • EISSN: 2514-9946
  • URL: /core/journals/the-british-journal-of-psychiatry
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Regarding the Treatment of General Paralysis

  • G. H. Monrad-Krohn (a1)
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