Sulfosin was first introduced by Schroeder (1) in the treatment of general paralysis and other syphilitic infections of the nervous system, and later its use was extended to the treatment of schizophrenia. He stated that the results were encouraging, and that this method of treatment was worthy of an extended trial. Loberg (2) treated 100 schizophrenic patients with sulfosin, and of these 49 had remissions in varying degrees. In a later report (3) he stated he had treated 135 patients, of whom 62 improved but only 12 had permanent remissions. Marcuse and Kallmann (4) treated 46 patients, 16 of whom were improved; Salinger (5) treated 16 patients, of whom 2 had remissions and 14 were unchanged.
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