Hostname: page-component-848d4c4894-wg55d Total loading time: 0 Render date: 2024-05-20T11:08:47.638Z Has data issue: false hasContentIssue false
  • English
  • Français

Postoperative radiotherapy for pigmented villonodular synovitis (PVNS): case series and literature review

Published online by Cambridge University Press:  29 April 2021

T. Al-Hajri Open the ORCID record for T. Al-Hajri [Opens in a new window] ,
K. Al-Madailwi  and
J. Riromar
T. Al-Hajri*
Affiliation:
National Oncology Center, Royal Hospital, Muscat, Oman
K. Al-Madailwi
Affiliation:
National Oncology Center, Royal Hospital, Muscat, Oman
J. Riromar
Affiliation:
National Oncology Center, Royal Hospital, Muscat, Oman
*
Author for correspondence: Thuraya Al-Hajri, National Oncology Center, Royal Hospital, Royal Hospital Area, Al-Ghubra, P.O. Box 1331, Muscat, Oman. Tel: 0968 92854500. Fax: 096824627004. E-mail: x_thuraya_x@hotmail.com
Get access Rights & Permissions [Opens in a new window]

Abstract

Purpose:

Pigmented villonodular synovitis (PVNS) is a rare benign proliferative disease of the synovium with locally aggressive behaviour. We reviewed our experience using external beam radiotherapy (RT) in the treatment of PVNS.

Method:

We report five cases of PVNS who underwent Arthroscopic Synovectomy followed by postoperative RT in National Oncology centre in Oman. The total dose RT ranges between 30 and 36 Gray (Gy) Three-dimensional radiotherapy technique.

Conclusion:

Postoperative RT is effective in preventing disease recurrence and should be offered following maximal cytoreduction to enhance local control in PVNS.

Keywords

arthroscopic synovectomyexternal beam radiotherapypigmented villonodular synovitis (PVNS)
Type
Case Study
Information
Journal of Radiotherapy in Practice , Volume 22 , 2023 , e2
Check for updates
Copyright
© The Author(s), 2021. Published by Cambridge University Press

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Gouin, F, Noailles, T. Localized and diffuse forms of tenosynovial giant cell tumor (formerly giant cell tumor of the tendon sheath and pigmented villonodular synovitis). Orthop Traumatol Surg Res 2017; 103 (1): S91–S97.CrossRefGoogle ScholarPubMed
Heijden, L van der, Gibbons, C L M H, Dijkstra, P D S et al. The management of diffuse-type giant cell tumour (pigmented villonodular synovitis) and giant cell tumour of tendon sheath (nodular tenosynovitis). J Bone Jt Surg 2012; 94-B (7): 882–888.CrossRefGoogle ScholarPubMed
Somerhausen, N S, Fletcher, C D M. Diffuse-type giant cell tumor: clinicopathologic and immunohistochemical analysis of 50 cases with extraarticular disease. Am J Surg Pathol 2000; 24 (4): 479–492.CrossRefGoogle ScholarPubMed
Oehler, S, Hans, G, Fassbender, D et al. Cell populations involved in pigmented villonodular synovitis of the knee. The Journal of Rheumatology 2000; 27 (2): 463–470.Google ScholarPubMed
Myers, B W, Masi, A T, Feigenbaum, S. Pigmented villonodular synovitis and Tenosynovitis: a clinical epidemiologic study of 166 cases and literature review. Medicine (Baltimore) 1980; 59 (3): 223–238.CrossRefGoogle ScholarPubMed
Cheng, X G, You, Y H, Liu, W, Zhao, T, Qu, H. MRI features of pigmented villonodular synovitis (PVNS). Clin Rheumatol 2004; 23: 31–34.CrossRefGoogle ScholarPubMed
Schwartz, H S, Unni, K, Pritchard, D J. Pigmented villonodular synovitis. A retrospective review of affected large joints. Clin Orthop Relat Res 1989; 247: 243–255.CrossRefGoogle Scholar
Ponti, A De, Sansone, V, Malchere, M. Result of arthroscopic treatment of pigmented villonodular synovitis of the knee. Arthrosc J Arthrosc Relat Surg 2003; 19 (6): 602–607.CrossRefGoogle ScholarPubMed
Fang, Y, Zhang, Q. Recurrence of pigmented villonodular synovitis of the knee: a case report with review of literature on the risk factors causing recurrence. Medicine (Baltimore) [Internet]. 2020; 99 (16): e19856. https://journals.lww.com/mdjournal/fulltext/2020/04170/recurrence_of_pigmented_villonodular_synovitis_of.93.aspx CrossRefGoogle ScholarPubMed
O’Sullivan, B, Cummings, B, Catton, C et al. Outcome following radiation treatment for high-risk pigmented villonodular synovitis. Int J Radiat Oncol Biol Phys 1995; 32 (3): 777–786.CrossRefGoogle ScholarPubMed
Blanco, C E R, Leon, H O, Guthrie, T B. Combined partial arthroscopic synovectomy and radiation therapy for diffuse pigmented villonodular synovitis of the knee. Arthrosc J Arthrosc Relat Surg 2001; 17 (5): 527–531.CrossRefGoogle ScholarPubMed
de Carvalho, L H Jr, Soares, L F M, Goncalves, M B J, Temponi, E F, Melo Silva, O de Jr. Long-term success in the treatment of diffuse pigmented villonodular synovitis of the knee with subtotal synovectomy and radiotherapy. Arthrosc J Arthrosc Relat Surg 2012; 28 (9): 1271–1274.CrossRefGoogle ScholarPubMed
Griffin, A M, Ferguson, P C, Catton, C N et al. Long- term outcome of the treatment of high- risk tenosynovial giant cell tumor/pigmented villonodular synovitis with radiotherapy and surgery. Cancer 2012; 118 (19): 4901–4909.CrossRefGoogle ScholarPubMed
Heyd, R, Seegenschmiedt, M H, Micke, O. The role of external beam radiation therapy in the adjuvant treatment of pigmented villonodular synovitis. Z Orthop Unfall 2011; 149 (6): 677–682.CrossRefGoogle ScholarPubMed
Park, G, Young, S, Jong, H et al. Low-dose external beam radiotherapy as a postoperative treatment for patients with diffuse pigmented villonodular synovitis of the knee: 4 recurrences in 23 patients followed for mean 9 years. Acta Orthopaedica 2012; 83 (3): 256–260.CrossRefGoogle ScholarPubMed
Horoschak, M, Tran, P T, Bachireddy, P et al. External beam radiation therapy enhances local control in pigmented villonodular synovitis. Int J Radiat Oncol Biol Phys 2009; 75 (1): 183–187.CrossRefGoogle ScholarPubMed
Park, G, Kim, Y S, Kim, J H et al. Low-dose external beam radiotherapy as a postoperative treatment for patients with diffuse pigmented villonodular synovitis of the knee. Acta Orthop 2012; 83 (3): 256–260.CrossRefGoogle ScholarPubMed
Tap, W D, Wainberg, Z A, Anthony, S P et al. Structure-guided blockade of CSF1R kinase in tenosynovial giant-cell tumor. N Engl J Med 2015; 373: 428–437.CrossRefGoogle ScholarPubMed