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Modulation of Mesenchymal Stem Cell Migration using Programmable Polymer Sheet Actuators

Published online by Cambridge University Press:  11 May 2020

Zijun Deng ,
Weiwei Wang ,
Xun Xu ,
Nan Ma  and
Andreas Lendlein
Zijun Deng
Affiliation:
Institute of Biomaterial Science and Berlin-Brandenburg Centre for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, 14513 Teltow, Germany Institute of Chemistry and Biochemistry, Free University of Berlin, 14195 Berlin, Germany
Weiwei Wang
Affiliation:
Institute of Biomaterial Science and Berlin-Brandenburg Centre for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, 14513 Teltow, Germany
Xun Xu
Affiliation:
Institute of Biomaterial Science and Berlin-Brandenburg Centre for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, 14513 Teltow, Germany
Nan Ma*
Affiliation:
Institute of Biomaterial Science and Berlin-Brandenburg Centre for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, 14513 Teltow, Germany Institute of Chemistry and Biochemistry, Free University of Berlin, 14195 Berlin, Germany
Andreas Lendlein*
Affiliation:
Institute of Biomaterial Science and Berlin-Brandenburg Centre for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, 14513 Teltow, Germany Institute of Chemistry and Biochemistry, Free University of Berlin, 14195 Berlin, Germany Institute of Chemistry, University of Potsdam, 14469 Potsdam, Germany
*
*To whom correspondence should be addressed: Prof. Dr. Nan Ma, Prof. Dr. Andreas Lendlein Email: nan.ma@hzg.de, andrease.lendlein@hzg.de
*To whom correspondence should be addressed: Prof. Dr. Nan Ma, Prof. Dr. Andreas Lendlein Email: nan.ma@hzg.de, andrease.lendlein@hzg.de
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Abstract

Recruitment of mesenchymal stem cells (MSCs) to damaged tissue is a crucial step to modulate tissue regeneration. Here, the migration of human adipose-derived stem cells (hADSCs) responding to thermal and mechanical stimuli was investigated using programmable shape-memory polymer actuator (SMPA) sheets. Changing the temperature repetitively between 10 and 37 °C, the SMPA sheets are capable of reversibly changing between two different pre-defined shapes like an artificial muscle. Compared to non-actuating sheets, the cells cultured on the programmed actuating sheets presented a higher migration velocity (0.32 ± 0.1 vs. 0.57 ± 0.2 μm/min). These results could motivate the next scientific steps, for example, to investigate the MSCs pre-loaded in organoids towards their migration potential.

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MRS Advances , Volume 5 , Issue 46-47: Soft Materials and Biomaterials , 2020 , pp. 2381 - 2390
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Copyright © Materials Research Society 2020

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