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Development of a Flexible MIP-Based Biosensor Platform for the Thermal Detection of Neurotransmitters

  • Kai Betlem (a1), Michael P. Down (a1), Christopher W. Foster (a1), Shamima Akthar (a1), K. Eersels (a2), B. van Grinsven (a2), T.J. Cleij (a2), C.E. Banks (a1) and M. Peeters (a1)...
Abstract

We have developed high affinity Molecularly Imprinted Polymers (MIPs) for neurotransmitters such as dopamine, noradrenaline and caffeine. These polymer particles are mixed within the bulk of screen-printed ink allowing masss-producible bulk modified MIP Screen-Printed Electrodes (MIP-SPEs) to be realised. We have explored different SPE supporting surfaces, such as polyester, tracing paper and household-printing paper. The performance of those MIP-SPEs is studied using the Heat-Transfer Method (HTM), a patented thermal method. With the combination of screen-printing techniques and thermal detection, it is possible to develop a portable sensor platform that is capable of low-cost and straightforward detection of biomolecules on-site. In the future, this unique sensor architecture holds great promise for the use in biomedical devices.

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Corresponding author
*(Email: m.peeters@mmu.ac.uk)
References
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[1]Haupt, K. and Mosbach, K., Chem. Rev. 100, 2495 (2000).
[2]Wulff, G., Chem. Rev. 102, 1, (2002).
[3]Spivak, D. A., Adv. Drug. Del. Rev. 57, 1779, (2005).
[4]Casadio, S., Lowdon, J.W., Betlem, K., Ueta, J.T., Foster, C.W., Cleij, T.J., van Grinsven, B., Sutcliffe, O.B., Banks, C.E. and Peeters, M., Chem. Eng. J. 315, 459, (2017).
[5]van Grinsven, B, Eersels, K., Peeters, M., Losada-Perez, P., Vandenryt, T., Cleij, T.J. and Wagner, P., ACS Appl. Mater. Interfaces, 6, 16, 13309, (2014).
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MRS Advances
  • ISSN: -
  • EISSN: 2059-8521
  • URL: /core/journals/mrs-advances
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