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Fabrication of ultrathin and flexible graphene-based devices for in vivo neuroprosthetics

  • Dmitry Kireev (a1), Pegah Shokoohimehr (a1), Mathis Ernst (a1), Viviana Rincón Montes (a1), Kagithiri Srikantharajah (a1), Vanessa Maybeck (a1), Bernhard Wolfrum (a1) (a2) and Andreas Offenhäusser (a1)...

Abstract

Graphene based devices have already proven to be extremely sensitive and very useful in a wide spectrum of bioelectronics research. In the manuscript we describe a method to fabricate arrays of graphene-based probes, requiring minimal number of fabrication steps, while maintaining overall device functionality. These polyimide-based probes are approximately 6 µm thick, therefore ultraflexible, yet robust and stable. Devices, such as graphene field effect transistors (GFETs) and graphene multielectrode arrays (GMEAs) have been designed, fabricated and tested for their performance. The flexible GFETs exhibit sensitivity, i.e. transconductance up to 700 µS/V, which an order of magnitude larger compared to typical silicon transistors. Multiple probe per wafer design allows us to fabricate different kinds of devices on one 4-inch wafer, consequently increasing a possible range of applications from e.g. retinal to cortical neuroprosthetics.

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1.Lebedev, M.A. and Nicolelis, M.A.L., Trends Neurosci. 29, 536 (2006).
2.Lacour, S.P., Courtine, G., and Guck, J., Nat. Rev. Mater. 1, 16063 (2016).
3.Weltman, A., Yoo, J., and Meng, E., Micromachines 7, (2016).
4.Fromherz, P., Eur. Biophys. J. 28, 254 (1999).
5.Qing, Q., Pal, S.K., Tian, B., Duan, X., Timko, B.P., Cohen-Karni, T., Murthy, V.N., and Lieber, C.M., Proc. Natl. Acad. Sci. U. S. A. 107, 1882 (2010).
6.Wang, P. and Liu, Q., Cell-Based Biosensors: Principles and Applications (Artech House, Boston, MA, 2009).
7.Fabbro, A., Scaini, D., León, V., Vázquez, E., Cellot, G., Privitera, G., Lombardi, L., Torrisi, F., Tomarchio, F., Bonaccorso, F., Bosi, S., Ferrari, A.C., Ballerini, L., and Prato, M., ACS Nano 10, 615 (2016).
8.Veliev, F., Briançon-Marjollet, A., Bouchiat, V., and Delacour, C., Biomaterials 86, 33 (2016).
9.Blaschke, B.M., Tort-Colet, N., Guimerà-Brunet, A., Weinert, J., Rousseau, L., Heimann, A., Drieschner, S., Kempski, O., Villa, R., Sanchez-Vives, M. V., and Garrido, J.A., 2D Mater. 4, 25040 (2017).
10.Kuzum, D., Takano, H., Shim, E., Reed, J.C., Juul, H., Richardson, A.G., de Vries, J., Bink, H., Dichter, M.A., Lucas, T.H., Coulter, D.A., Cubukcu, E., and Litt, B., Nat. Commun. 5, 5259 (2014).
11.Kireev, D., Seyock, S., Lewen, J., Maybeck, V., Wolfrum, B., and Offenhäusser, A., Adv. Healthc. Mater. 6, 1601433 (2017).
12.Kireev, D., Seyock, S., Ernst, M., Maybeck, V., Wolfrum, B., and Offenhäusser, A., Biosensors 7, 1 (2016).
13.Kireev, D., Zadorozhnyi, I., Qiu, T., Sarik, D., Brings, F., Wu, T., Seyock, S., Maybeck, V., Lottner, M., Blaschke, B., Garrido, J., Xie, X., Vitusevich, S., Wolfrum, B., and Offenhausser, A., IEEE Trans. Nanotechnol. 16, 140 (2017).
14.Kireev, D., Brambach, M., Seyock, S., Maybeck, V., Fu, W., Wolfrum, B., and Offenhäusser, A., Sci. Rep. 7, 6658 (2017).
15.Park, D.-W., Schendel, A.A., Mikael, S., Brodnick, S.K., Richner, T.J., Ness, J.P., Hayat, M.R., Atry, F., Frye, S.T., Pashaie, R., Thongpang, S., Ma, Z., and Williams, J.C., Nat. Commun. 5, 5258 (2014).
16.Brusius, J., “3-dimensionale penetrierende Multielektrodenarrays zur Stimulation und Ableitung in der Retina,” Ph.D. thesis, RWTH Aachen, Aachen, 2015
17.Drieschner, S., Guimerà, A., Cortadella, R.G., Viana, D., Makrygiannis, E., Blaschke, B.M., Vieten, J., and Garrido, J.A., J. Phys. D. Appl. Phys. 50, 95304 (2017).
18.Kireev, D., Sarik, D., Wu, T., Xie, X., Wolfrum, B., and Offenhäusser, A., Carbon N. Y. 107, 319 (2016).
19.Kotman, N., (2008) “Bidirectional Coupling of Neurons with a Microchip Integrating Microelectrodes and Field-Effect Transistors” Ph.D. thesis, RWTH Aachen, Aachen, 2008.
20.Irimia-Vladu, M., Głowacki, E.D., Voss, G., Bauer, S., and Sariciftci, N.S., Mater. Today 15, 340 (2012).
21.Krause, M., Ingebrandt, S., Richter, D., Denyer, M., Scholl, M., Sprössler, C., and Offenhäusser, A., Sensors Actuators, B Chem. 70, 101 (2000).
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MRS Advances
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