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Regenerative Engineering-The Convergence Quest

Published online by Cambridge University Press:  14 January 2018

Cato Laurencin  and
Naveen Nagiah
Cato Laurencin*
Affiliation:
Institute for Regenerative Engineering, University of Connecticut Health Center, Farmington, Connecticut, United States of America Raymond and Beverly Sackler Center for Biomedical, Biological, Physical and Engineering Sciences, Farmington, Connecticut, United States of America Department of Orthopaedic Surgery, University of Connecticut Health Center, Farmington, Connecticut, United States of America Department of Materials Science & Engineering, University of Connecticut, Storrs, Connecticut, United States of America
Naveen Nagiah
Affiliation:
Institute for Regenerative Engineering, University of Connecticut Health Center, Farmington, Connecticut, United States of America
*
*(Email: Laurencin@uchc.edu)
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Abstract

We define Regenerative Engineering as a Convergence of Advanced Materials Science, Stem Cell Science, Physics, Developmental Biology, and Clinical Translation. We believe that an “un-siloed’ technology approach will be important in the future to realize grand challenges such as limb and organ regeneration. We also believe that biomaterials will play a key role in achieving overall translational goals. Through convergence of a number of technologies, with advanced materials science playing an important role, we believe the prospect of engaging future grand challenges is possible. Regenerative Engineering as a field is particularly suited for solving clinical problems that are relevant today. The paradigms utilized can be applied to the regeneration of tissue in the shoulder where tendon and muscle currently have low levels of regenerative capability, and the consequences, especially in alternative surgical solutions for massive tendon and muscle loss at the shoulder have demonstrated significant morbidity. Polymer, polymer-cell, and polymer biological factor, and polymer-physical systems can be utilized to propose a range of solutions to shoulder tissue regeneration. The approaches, possibilities, limitations and future strategies, allow for a variety of clinical solutions in musculoskeletal disease treatment.

Keywords

biomaterialbiomedicalbiological

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MRS Advances , Volume 3 , Issue 30: Biomaterials and Soft Materials , 2018 , pp. 1665 - 1670
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Copyright © Materials Research Society 2018 

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