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Synthesis and Characterization of Multiblock Poly(Ester-Amide-Urethane)s

Published online by Cambridge University Press:  10 July 2017

Xingzhou Peng ,
Marc Behl ,
Pengfei Zhang ,
Magdalena Mazurek-Budzyńska ,
Yakai Feng  and
Andreas Lendlein
Xingzhou Peng
Affiliation:
Institute of Biomaterial Science and Berlin-Brandenburg Centre for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, 14513 Teltow, Germany School of Chemical Engineering and Technology, Tianjin University, Tianjin 300350, China Institute of Chemistry, University of Potsdam, 14476 Potsdam, Germany Tianjin University-Helmholtz-Zentrum Geesthacht Joint Laboratory for Biomaterials and Regenerative Medicine, 14513 Teltow, Germany
Marc Behl
Affiliation:
Institute of Biomaterial Science and Berlin-Brandenburg Centre for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, 14513 Teltow, Germany Institute of Chemistry, University of Potsdam, 14476 Potsdam, Germany
Pengfei Zhang
Affiliation:
Institute of Biomaterial Science and Berlin-Brandenburg Centre for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, 14513 Teltow, Germany School of Chemical Engineering and Technology, Tianjin University, Tianjin 300350, China Institute of Chemistry, University of Potsdam, 14476 Potsdam, Germany
Magdalena Mazurek-Budzyńska
Affiliation:
Institute of Biomaterial Science and Berlin-Brandenburg Centre for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, 14513 Teltow, Germany
Yakai Feng
Affiliation:
School of Chemical Engineering and Technology, Tianjin University, Tianjin 300350, China Tianjin University-Helmholtz-Zentrum Geesthacht Joint Laboratory for Biomaterials and Regenerative Medicine, 14513 Teltow, Germany
Andreas Lendlein*
Affiliation:
Institute of Biomaterial Science and Berlin-Brandenburg Centre for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, 14513 Teltow, Germany Institute of Chemistry, University of Potsdam, 14476 Potsdam, Germany Tianjin University-Helmholtz-Zentrum Geesthacht Joint Laboratory for Biomaterials and Regenerative Medicine, 14513 Teltow, Germany
*
*(Email: andreas.lendlein@hzg.de)
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Abstract

In this study, a multiblock copolymer containing oligo(3-methyl-morpholine-2,5-dione) (oMMD) and oligo(3-sec-butyl-morpholine-2,5-dione) (oBMD) building blocks obtained by ring-opening polymerization (ROP) of the corresponding monomers, was synthesized in a polyaddition reaction using an aliphatic diisocyanate. The multiblock copolymer (pBMD-MMD) provided a molecular weight of 40,000 g·mol−1, determined by gel permeation chromatography (GPC). Incorporation of both oligodepsipeptide segments in multiblock copolymers was confirmed by 1H NMR and Matrix Assisted Laser Desorption/Ionization Time Of Flight Mass Spectroscopy (MALDI-TOF MS) analysis. pBMD-MMD showed two separated glass transition temperatures (61 °C and 74 °C) indicating a microphase separation. Furthermore, a broad glass transition was observed by DMTA, which can be attributed to strong physical interaction i.e. by H-bonds formed between amide, ester, and urethane groups of the investigated copolymers. The obtained multiblock copolymer is supposed to own the capability to exhibit strong physical interactions.

Keywords

biomaterialpolymerpolymerization
Type
Articles
Information
MRS Advances , Volume 2 , Issue 47: Soft Materials and Biomaterials , 2017 , pp. 2551 - 2559
Copyright
Copyright © Materials Research Society 2017 

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References

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