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Expanding Frontiers in Biomaterials

  • Samuel I. Stupp, Jack J.J.M. Donners, Liang-shi Li and Alvaro Mata

This article celebrating Arthur von Hippel's career considers the expanding frontiers in the field of biomaterials, a subject that intrigued him given his interests in the molecular engineering of materials. The interface of materials science and biology started to develop decades ago when synthetic materials were first used to repair parts of the human body. An exciting transformation is now occurring in the field, as advances in biology are used to engineer bioactive materials at the molecular level. The transformation is going further to other frontiers that include the use of sophisticated materials to obtain biological information and learn biology, the creation of materials that imitate biological microstructures and functions, and the manipulation of organisms to create artificial materials.

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1.Hippel, A. von, Mater. Res. Bull. 14 (1979) p. 273.
2.Ratner, B.D., Biomaterials Science: An Introduction to Materials in Medicine (Elsevier Academic Press, San Diego, 2004).
3.Anderson, D.G., Burdick, J.A., and Langer, R., Science 305 (2004) p. 1923.
4.Hench, L.L. and Ethridge, E.C., Biomaterials: An Interfacial Approach (Academic Press, San Diego, 1982).
5.Dumitriu, S., ed., Polymeric Biomaterials, 2nd ed. (Marcel Dekker, New York, 2002).
6.Bronzio, J.D., The Biomedical Engineering Handbook (CRC Press, Boca Raton, Fla., 1995).
7.Williams, H.P., Br. J. Ophthalmol. 85 (9) (2001) p. 1022.
8.DeWall, R.A., Qasim, N., and Carr, L., Ann. Thorac. Surg. 69 (2000) p. 1612.
9.Stupp, S.I., MRS Bull. 30 (7) (2005) p. 546.
10.Beniash, E., Hartgerink, J.D., Storrie, H., Stendahl, J.C., and Stupp, S.I., Acta Biomater. 1 (2005) p. 385.
11.Sarkar, S., Dadhania, M., Rourke, P., Desai, T.A., and Wong, J.Y., Acta Biomater. 1 (2005) p. 93.
12.Shin, M., Matsuda, K., Ishii, O., Terai, H., Kaazempur-Mofrad, M., Borenstein, J., Detmar, M., and Vacanti, J.P., Biomed. Microdevices 6 (4) (2004) p. 269.
13.Storrie, H. and Stupp, S.I., Biomaterials 26 (2005) p. 5492.
14.Furstner, R., Barthlott, W., and Walzel, P., Langmuir 21 (2005) p. 956.
15.Lai, S.C.S, “Mimicking Nature: Physical Basis and Artificial Synthesis of the Lotus-Effect,” Universiteit Leiden (August 2003), (accessed September 2005.)
16. Photograph of a water lily, us-2.jpg (accessed September 2005).
17.Geim, A.K., Dubonos, S.V., Grigorieva, I.V., Novoselov, K.S., Zhukov, A.A., and Shapo-val, S.Y., Nature Mater. Lett. (2003) p. 461.
18. “How Geckos Stick to Walls,” www.,autumn/private/u38j47a0t/ (accessed September 2005).
19.Aizenberg, J., Adv. Mater. 16 (2004) p. 1295.
20. The Whitaker Foundation, “Imaging Prostate Cancer with Quantum Dots,” www. (accessed September 2005).
21. Office of Naval Research, “Image Gallery: General Science and Technology,” general (accessed September 2005).
22.Wu, X., Liu, H., Liu, J., Haley, K.N., Treadway, J.A., Larson, J.P., Ge, N., Peale, F., and Bruchez, M.P., Nature Biotech. 21 (2003) p. 41.
23.Rosi, N.L. and Mirkin, C.A., Chem. Rev. 105 (2005) p. 1547.
24.Groves, J.T., Angew. Chem. Int. Ed. 44 (2005) p. 3524.
25.Brock, A., Chang, E., Ho, C.C., LeDuc, P., Jiang, X., Whitesides, G.M., Ingber, D.E., Langmuir 19 (2003) p. 1611.
26.Tan, J.L., Tien, J., Pirone, D., Gray, D.S., and Chen, C.S., Proc. Natl. Acad. Sci. USA 100 (2003) p. 1484.
27.Mao, C., Solis, D.J., Reiss, B.D., Kottmann, S.T., Sweeney, R.Y., Hayhurst, A., Georgiou, G., Iverson, B., and Belcher, A.M., Science 303 (2004) p. 213.
28.Whaley, S.R., English, D.S., Hu, E.L., Barbara, P.F., and Belcher, A.M., Nature 405 (2000) p. 665.
29.Cappello, J., Crissman, J., Dorman, M., Mikolajczak, M., Textor, G., Marquet, M., and Ferrari, F., Biotechnol. Progr. 6 (1990) p. 198.
30.Spoerke, E.D. and Stupp, S.I., Biomaterials 26 (2005) p. 5120.
31.Spoerke, E.D. and Stupp, S.I., J. Biomed. Mater. Res. 67A (2003) p. 960.
32.Lanza, R.P., Langer, R., and Vacanti, J., Principles of Tissue Engineering (Academic Press, San Diego, 2000).
33.Richardson, T.P., Peters, M.C., Ennett, A.B., and Mooney, D.J., Nature Biotech. 19 (2001) p. 1029.
34.Mata, A., doctoral dissertation, Cleveland State University (2005).
35.Mata, A., Fleischman, A.J., and Roy, S., “Microfabricated 3D Scaffolds for Tissue Engineering Applications,” in Nanoscale Materials Science in Biology and Medicine, edited by Laurencin, C.T. and Botchwey, E.A. (Mater Res. Soc. Symp. Proc. 845, Warrendale, PA, 2005) p. AA4.3.1.
36.Tan, W. and Desai, T.A., Biomaterials 25 (2004) p. 1355.
37.Folch, A., Mezzour, S., During, M., Hurtado, O., Toner, M., and Muller, R., Biomed. Microdevices 2 (3) (2000) p. 207.
38.Mata, A., Fleischman, A.J., and Roy, S., Proc. Am. Soc. Precision Eng. Spring Topical Meeting on Precision Micro/Nano-Scale Polymer-Based Component and Device Fabrication, Vol. 35 (2005) p. 15.
39.Lendlein, A. and Langer, R., Science 296 (2002) p. 1673.
40.Yang, J., Yamato, M., and Okano, T., MRS Bull. 30 (3) (2005) p. 189.
41.Nishida, K., Yamato, M., Hayashida, Y., Watanabe, K., Maeda, N., Watanabe, H., Yamamoto, K., Nagai, S., Kikuchi, A., Tano, Y., and Okano, T., Transplantation 77 (2004) p. 379.
42.Shimizu, T., Yamato, M., Isoi, Y., Akutsu, T., Setomaru, T., Abe, K., Kikuchi, A., Umezu, M., and Okano, T., Circ. Res. 90 (2002) p. e40.
43.Lahann, J. and Langer, R., MRS Bull. 30 (3) (2005) p. 185.
44.Hartgerink, J.D., Beniash, E., and Stupp, S.I., Science 294 (2001) p. 1684.
45.Silva, G.A., Czeisler, C., Niece, K.L., Beniash, E., Harrington, D., Kessler, J.A., and Stupp, S.I., Science 303 (2004) p. 1352.
46.Hartgerink, J.D., Beniash, E., and Stupp, S.I., Proc. Natl. Acad. Sci. USA 99 (2002) p. 5133.
47.Niece, K.L., Hartgerink, J.D., Donners, J., and Stupp, S.I., J. Am. Chem. Soc. 125 (2003) p. 7146.
48.Service, R.F., Science 308 (2005) p. 44.
49.Lehn, J.-M., Les Prix Nobel (1988) p. 129.
50.Behanna, H.A., Donners, J., Gordon, A.C., and Stupp, S.I., J. Am. Chem. Soc. 127 (2005) p. 1193.
51.Bull, S.R., Guler, M.O., Bras, R.E., Meade, T.J., and Stupp, S.I., Nano Lett. 5 (2005) p. 1.
52.Guler, M.O., Pokorski, J.K., Appella, D.H., and Stupp, S.I., Bioconjug. Chem., 16 (2005) p. 501.
53.Spolenak, R., Stanislav, G., and Arzt, E., Acta Biomater. 1 (2005) p. 5.
54.Autumn, K. and Peattie, A.M., Integr. Comp. Biol. 42 (2002) p. 1081.
55.Breslow, R., Chem. Rec. (2000) p. 3.
56.Kisailus, D., Najarian, M., Weaver, J.C., and Morse, D.E., Adv. Mater. 17 (2005) p. 1234.
57.Du, C., Falini, G., Fermani, S., Abbott, C., and Moradian-Oldak, J., Science 307 (2005) p. 1450.
58.Seeman, N.C., Trends Biochem. Sci. 30 (2005) p. 119.
59.Niemeyer, C.M., Curr. Opin. Chem. Biol. 4 (2000) p. 609.
60.Winfree, E., Liu, F., Wenzler, L.A., and Seeman, N.C., Nature 394 (1998) p. 539.
61.Mao, C., Sun, W., and Seeman, N.C., Nature 386 (1997) p. 137.
62.Chen, J. and Seeman, N.C., Nature 350 (1991) p. 631.
63.Mao, C., Sun, W., Shen, Z., and Seeman, N.C., Nature 397 (1999) p. 144.
64.Yan, H., Zhang, X., Shen, Z., and Seeman, N.C., Nature 415 (2002) p. 62.
65.Warner, M.G. and Hutchison, J.E., Nature Mater. 2 (2003) p. 272.
66.Nakao, H., Shiigi, H., Yamamoto, Y., Tokonami, S., Nagaoka, T., Sugiyama, S., and Ohtani, T., Nano Lett. 3 (2003) p. 1391.
67.Li, L.-S. and Stupp, S.I., Angew. Chem. Int. Ed. 44 (2005) p. 1833.
68.Yang, S., Chen, G., Megens, M., Ullal, C.K., Han, Y.J., Rapaport, R., Thomas, E.L, and Aizenberg, J., Adv. Mater., 17 (4) (2005) p. 435.
69.Alivisatos, P., Nature Biotechnol. 22 (2004) p. 47.
70.Bruchez, M. Jr. , Moronne, M., Gin, P., Weiss, S., and Alivisatos, A.P., Science 281 (1998) p. 2013.
71.Chan, W.C.W. and Nie, S., Science 281 (1998) p. 2016.
72.Michalet, X., Pinaud, F.F., Bentolila, L.A., Tsay, J.M., Doose, S., Li, J.J., Sundaresan, G., Wu, A.M., Gambhir, S.S., and Weiss, S., Science 307 (2005) p. 538.
73.Medintz, I.L., Uyeda, H.T., Goldman, E.R., and Mattoussi, H., Nature Mater. 4 (2005) p. 435.
74.Kim, S., Lim, Y.T., Soltesz, E.G., Grand, A.M. De, Lee, J., Nakayama, A., Parker, J.A., Mihaljevic, T., Laurence, R.G., Dor, D.M., Cohn, L.H., Bawendi, M.G., and Frangioni, J.V., Nature Biotechnol. 22 (2004) p. 93.
75.Taton, T.A., Mirkin, C.A., and Letsinger, R.L., Science 289 (2000) p. 1757.
76.Thaxton, C.S., Rosi, N.L., and Mirkin, C.A., MRS Bull. 30 (5) (2005) p. 376.
77.Elghanian, R., Storhoff, J.J., Mucic, R.C., Letsinger, R.L., and Mirkin, C.A., Science 277 (1997) p. 1078.
78.Cao, Y.W.C., Jin, R.C., and Mirkin, C.A., Science 297 (2002) p. 1536.
79.Jackson, J.B., Westcott, S.L., Hirsch, L.R., West, J.L., and Halas, N.J., Appl. Phys. Lett. 82 (2003) p. 257.
80.Hirsch, L.R., Jackson, J.B., Lee, A., Halas, N.J., and West, J., Anal. Chem. 75 (2003) p. 2377.
81.Nam, J.-M., Stoeva, S., and Mirkin, C.A., J. Am. Chem. Soc. 126 (2004) p. 5932.
82.Yang, P.D., MRS Bull. 30 (2) (2005) p. 85.
83.Sirbuly, D.J., Law, M., Pauzauskie, P., Yan, H., Maslov, A.V., Knutsen, K., Ning, C.-Z., Saykally, R.J., and Yang, P., Proc. Natl. Acad. Sci. USA 102 (2005) p. 7800.
84.Kong, J., Franklin, N., Zhou, C., Peng, S., Cho, J.J., and Dai, H., Science 287 (2000) p. 622.
85.Collins, P.G., Bradley, K., Ishigami, M., and Zettl, A., Science 287 (2000) p. 1801.
86.Chen, R.J., Bangsaruntip, S., Drouvalakis, K.A., Kam, N. Wong Shi, Shim, M., Li, Y., Kim, W., Utz, P.J., and Dai, H., Proc. Natl. Acad. Sci. USA 100 (2003) p. 4984.
87.Cui, Y., Wei, Q.Q., Park, H.K., and Lieber, C.M., Science 293 (2001) p. 1289.
88.Clément, O., Siauve, N., Cuénod, C-A., and Frija, G., Top. Magn. Reson. Imaging 9 (1998) p. 167.
89.Wang, Y.-X., Hussain, S.M., and Krestin, G.P., Eur. Radiol. 11 (2001) p. 2319.
90.Lawaczeck, R., Menzel, M., and Pietsch, H., Appl. Organomet. Chem. 18 (2004) p. 506.
91.Chilkoti, A. and Hubbell, J.A., MRS Bull. 30 (3) (2005) p. 175.
92.Xia, Y. and Whitesides, G.M., Angew. Chem. Int. Ed. 37 (1998) p. 550.
93.Nelson, C.M. and Chen, C.S., FEBS Lett. 514 (2002) p. 238.
94.Chen, C.S., Alonso, J.L., Ostuni, E., Whitesides, G.M., and Ingber, D.E., Biochem. Biophys. Res. Commun. 307 (2003) p. 355.
95.Bhatia, S.N., Balis, U.J., Yarmush, M.L., and Toner, M., FASEB J. 13 (1999) p. 1883.
96.Mrksich, M., MRS Bull. 30 (3) (2005) p. 180.
97.Raghavan, S. and Chen, C.S., Adv. Mater. 16 (15) (2004) p. 1303.
98.Chen, C.S., Jiang, X., and Whitesides, G.M., MRS Bull. 30 (3) (2005) p. 194.
99.Jiang, X. and Whitesides, G.M., Eng. Life Sci. 3 (12) (2003) p. 475.
100.Walker, G.M., Sai, J., Richmond, A., Stremler, M., Chung, C.Y., and Wikswo, J.P., Lab Chip 5 (2005) p. 611.
101.Takayama, S., Ostuni, E., LeDuc, , Naruse, K., Ingber, D.E., and Whitesides, G.M., Nature 411 (2001) p. 1016.
102.Groves, J.T., Ulman, N., and Boxer, S.G., Science 275 (1997) p. 651.
103.Yoshina-Ishii, C., Miller, G.P., Kraft, M.L., Kool, E.T., and Boxer, S.G., J. Am. Chem. Soc. 127 (2005) p. 1356.
104.Schonherr, H., Johnson, J.M., Lenz, P., Frank, C.W., and Boxer, S.G., Langmuir 20 (2004) p. 11600.
105.Baksh, M.M., Jaros, M., and Groves, J.T., Nature 427 (2004) p. 139.
106.Kam, L. and Boxer, S.G., Langmuir 19 (2003) p. 1624.
107.Grakoui, A., Bromley, S.K., Sumen, C., Davis, M.M., Shaw, A.S., Allen, P.M., and Dustin, M.L., Science 285 (1999) p. 221.
108.Curtis, A. and Wilkinson, C., Biomaterials 18 (1998) p. 1573.
109.Harrison, R.G., J. Exp. Zool. 17 (4) (1912) p. 521.
110.Brunette, D.M., Exp. Cell Res. 164 (1) (1986) p. 11.
111.Mata, A., Boehm, C., Fleischman, A.J., Muschler, G.M., and Roy, S., Biomed. Microdevices 4 (4) (2002) p. 267.
112.Mata, A., Boehm, C., Fleischman, A.J., Muschler, G.M., and Roy, S., J. Biomed. Mater. Res. 62 (2002) p. 499.
113.Braber, E.T. den, Jansen, H.V., Boer, M.J. de, Croes, H.J.E., Elwenspoek, M., Ginsel, L.A., and Jansen, J.A., J. Biomed. Mater. Res. 40 (1998) p. 425.
114.Craighead, H.G., Turner, S.W., Davis, R.C., James, C., Perez, A.M., John, P.M. St., Isaacson, M.S., Kam, L., Shain, W., Turner, J.N., and Banker, G., Biomed. Microdevices 1 (1998) p. 49.
115.Wilkinson, C.D.W., Riehle, M., Wood, M., Gallagher, J., and Curtis, A.S.G., Mater. Sci. Eng. C19 (2002) p. 263.
116.Deutsch, D., Motlagh, B., Russell, B., and Desai, T.A., J. Biomed. Mater. Res. 53 (2000) p. 267.
117.Sambrook, J., Fritsch, E.F., and Maniatis, T., Molecular Cloning (Cold Spring Harbor Laboratory Press, New York, 1986).
118Hest, J.C.M. van and Tirrell, D.A., Chem. Commun. (2001) p. 1897.
119.Pelka, W.A., Harden, J.L., McGrath, K.P., Wirtz, D., and Tirrell, D.A., Science 281 (1998) p. 389.
120.Yu, S.J.M., Conticello, V.P., Zhang, G.H., Kayser, C., Fournier, M.J., Mason, T.L., and Tirrell, D.A., Nature 389 (1997) p. 167.
121.Link, A.J., Mock, M.L., and Tirrell, D.A., Curr. Opin. Biotechnol. 14 (2003) p. 603.
122.Hohsaka, T. and Sisido, M., Curr. Opin. Chem. Biol. 6 (2002) p. 809.
123.Dougherty, D.A., Curr. Opin. Chem. Biol. 4 (2000) p. 645.
124.Wang, L., Brock, A., Herberich, B., and Schultz, P.G., Science 292 (2001) p.498.
125.Wang, L. and Schultz, P.G., Angew. Chem. Int. Ed. 44 (2005) p.34.
126.Silver, S., Gene 179 (1996) p. 9.
127.Gardea-Torresdey, J.L., Parsons, J.G., Gomez, E., Peralta-Videa, J., Troiani, H.E., Santiago, P., and Yacaman, M.J., Nano Lett. 2 (2002) p. 397.
128.Mukherjee, P., Ahmad, A., Mandal, D., Senapati, S., Sainkar, S.R., Khan, M.I., Ramani, R., Parischa, R., Ajayakumar, P.V., Alam, M., Sastry, M., and Kumar, R., Angew. Chem. Intl. Ed. 40 (2001) p. 3585.
129.Mukherjee, P., Ahmad, A., Mandal, D., Senapati, S., Sainkar, S.R., Khan, M.I., Parischa, R., Ajayakumar, P.V., Alam, M., Kumar, R., and Sastry, M., Nano Lett. 1 (2001) p. 515.
130.Dameron, C.T., Reese, R.N., Mehra, R.K., Kortan, A.R., Carroll, P.J., Steigerwald, M.L., Brus, L.E., and Winge, D.R., Nature 338 (1989) p. 596.
131.Ahmad, A., Mukherjee, P., Mandal, D., Senapati, S., Khan, M.I., Kumar, R., and Sastry, M., J. Am. Chem. Soc. 124 (2002) p.12108.
132.Douglas, T., Dickson, D.P.E., Betteridge, S., Charnock, J., Garner, C.D., and Mann, S., Science 269 (1995) p. 54.
133.Hoess, R.H., Chem. Rev 101 (2001) p. 3205.
134.Spoerke, E.D., Murray, N.D., Li, H., Brinson, L.C., Dunand, D.C., and Stupp, S.I., Acta Biomater. 1 (2005) p. 523.
135. Atomic force microscope and scanning electron microscope images provided by Jiang, Hongzhou and Harrington, Dr. Daniel A., respectively.
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