Skip to main content
×
×
Home

Mechanical Regulation of Cells by Materials and Tissues

  • Wendy E. Thomas (a1), Dennis E. Discher (a2) and V. Prasad Shastri (a3)
Abstract

Over the last dozen years, studies at the cell and tissue level have demonstrated that the function and fate of all cells, stem cells in particular, are affected by the collective physical properties of their microenvironments. Meanwhile, biophysical studies at the single molecule level have taught us a great deal about how mechanical forces affect the structure and function of proteins involved in the assembly of cells into tissues. Together, these molecular, cellular, and tissue studies provide insight into the process and importance of mechanotransduction, which is the process by which mechanical forces are transduced into biological signals. This insight should motivate biomimetic approaches to better control cell fate and tissue function.

Copyright
References
Hide All
1.Dembo, M., Wang, Y.L., Biophys. J. 76, 2307 (1999).
2.Balaban, N.Q., Schwarz, U.S., Riveline, D., Goichberg, P., Tzur, G., Sabanay, I., Mahalu, D., Safran, S., Bershadsky, A., Addadi, L., Geiger, B., Nat. Cell Biol. 3, 466 (2001).
3.du Roure, O., Saez, A., Buguin, A., Austin, R.H., Chavrier, P., Silberzan, P., Ladoux, B., Proc. Natl. Acad. Sci. U.S.A. 102, 2390 (2005).
4.Wang, H.B., Dembo, M., Wang, Y.L., Am. J. Physiol., Cell Physiol. 279, C1345 (2000).
5.Jacot, J.G., McCulloch, A.D., Omens, J.H., Biophys. J. 95, 3479 (2008).
6.Engler, A.J., Griffin, M.A., Sen, S., Bonnemann, C.G., Sweeney, H.L., Discher, D.E., J. Cell. Biol. 166, 877 (2004).
7.Engler, A.J., Sen, S., Sweeney, H.L., Discher, D.E., Cell 126, 677 (2006).
8.Flanagan, L.A., Ju, Y.E., Marg, B., Osterfield, M., Janmey, P.A., Neuroreport 13, 2411 (2002).
9.Georges, P.C., Miller, W.J., Meaney, D.F., Sawyer, E.S., Janmey, P.A., Biophys. J. 90, 3012 (2006).
10.Patel, P.N., Smith, C.K., Patrick, C.W., J. Biomed. Mater. Res. A 73A, 313 (2005).
11.Ferrari, G., Cusella-De Angelis, G., Coletta, M., Paolucci, E., Stornaiuolo, A., Cossu, G., Mavilio, F., Science 279, 1528 (1998).
12.Stolz, M., Raiteri, R., Daniels, A.U., VanLandingham, M.R., Baschong, W., Aebi, U., Biophys. J. 86, 3269 (2004).
13.Chowdhury, F., Na, S., Li, D., Poh, Y.C., Tanaka, T.S., Wang, F., Wang, N., Nat. Mater. 9, 82 (2010).
14.Engler, A.J., Carag-Krieger, C., Johnson, C.P., Raab, M., Tang, H.Y., Speicher, D.W., Sanger, J.W., Sanger, J.M., Discher, D.E., J. Cell. Sci. 121, 3794 (2008).
15.Lipski, A.M., Jaquiery, C., Choi, H., Eberli, D., Stevens, M., Martin, I., Chen, I.-W., Shastri, V.P., Adv. Mater. 19, 553 (2007).
16.Lipski, A.M., Pino, C.J., Haselton, F.R., Chen, I.W., Shastri, V. P., Biomaterials 29, 3836 (2008).
17.Martin, I., Suetterlin, R., Baschong, W., Heberer, M., Vunjak-Novakovic, G., Freed, L.E., J. Cell. Biochem. 83, 121 (2001).
18.Martin, I., Vunjak-Novakovic, G., Yang, J., Langer, R., Freed, L.E., Exp. Cell Res. 253, 681 (1999).
19.Atala, A., Curr. Opin. Biotechnol. 20, 575 (2009).
20.O'Brien, F.J., Harley, B.A., Yannas, I.V., Gibson, L.J., Biomaterials 26, 433 (2005).
21.Zeltinger, J., Sherwood, J.K., Graham, D.A., Mueller, R., Griffith, L.G., Tissue Eng. 7, 557 (2001).
22.Yannas, I.V., Lee, E., Orgill, D.P., Skrabut, E.M., Murphy, G.F., Proc. Natl. Acad. Sci. U.S.A. 86, 933 (1989).
23.Marshall, A.J., Irvin, C.A., Barker, T., Sage, E.H., Hauch, K.D., Ratner, B.D., Abstr. Pap. Am. Chem. Soc. 228, 407 (2004).
24.Lee, C.H., Shin, H.J., Cho, I.H., Kang, Y.M., Kim, I.A., Park, K.D., Shin, J.W., Biomaterials 26, 1261 (2005).
25.Na, S., Collin, O., Chowdhury, F., Tay, B., Ouyang, M., Wang, Y., Wang, N., Proc. Natl. Acad. Sci. U.S.A. 105, 6626 (2008).
26.Liu, B., Kim, T.J., Wang, Y.J. R. Soc. Interface 7, Suppl. 3, S365 (2010).
27.Puchner, E.M., Alexandrovich, A., Kho, A.L., Hensen, U., Schafer, L.V., Brandmeier, B., Grater, F., Grubmuller, H., Gaub, H.E., Gautel, M., Proc. Natl. Acad. Sci. U.S.A. 105, 13385 (2008).
28.Le Trong, I., Aprikian, P., Kidd, B., Forero, M., Tchesnokova, V., Interland, G., Vogel, V., Stenkamp, R.E., Sokurenko, E., Thomas, W.E., Cell 141, 645 (2010).
29.Springer, T.A., Proc. Natl. Acad. Sci. U.S.A. 106, 91 (2009).
30.del Rio, A., Perez-Jimenez, R., Liu, R., Roca-Cusachs, P., Fernandez, J.M., Sheetz, M.P., Science 323, 638 (2009).
31.Wipff, P.J., Rifkin, D.B., Meister, J.J., Hinz, B., J. Cell. Biol. 179, 1311 (2007).
32.Ahamed, J., Burg, N., Yoshinaga, K., Janczak, C.A., Rifkin, D.B., Coller, B.S., Blood 112, 3650 (2008).
33.Friedland, J.C., Lee, M.H., Boettiger, D., Science 323, 642 (2009).
34.Kong, F., Garcia, A.J., Mould, A.P., Humphries, M.J., Zhu, C., J. Cell. Biol. 185, 1275 (2009).
35.Thomas, W., Annu. Rev. Biomed. Eng. 10, 39 (2008).
36.Thomas, W.E., Vogel, V., Sokurenko, E., Annu. Rev. Biophys. 37, 399 (2008).
37.Tchesnokova, V., Aprikian, P., Yakovenko, O., Larock, C., Kidd, B., Vogel, V., Thomas, W., Sokurenko, E., J. Biol. Chem. 283, 7823 (2008).
38.Askari, J.A., Buckley, P.A., Mould, A.P., Humphries, M.J., J. Cell. Sci. 122, 165 (2009).
39.Phan, U.T., Waldron, T.T., Springer, T.A., Nat. Immunol. 7, 883 (2006).
40.Thomas, W., J. Cell. Biol. 174, 911 (2006).
41.Hytonen, V.P., Vogel, V., PLoS Comput. Biol. 4, e24 (2008).
42.Tarbell, J.M., Ebong, E.E., Sci. Signal. 1, 8 (2008).
43.Dahl, K.N., Ribeiro, A.J., Lammerding, J., Circ. Res. 102, 1307 (2008).
44.Smith, M.L., Gourdon, D., Little, W.C., Kubow, K.E., Eguiluz, R.A., Luna-Morris, S., Vogel, V., PLoS Biol. 5, e268 (2007).
45.Meng, F., Suchyna, T.M., Sachs, F.A., FEBS J. 275, 3072 (2008).
46.Iwai, S., Uyeda, T.Q., Proc. Natl. Acad. Sci. U.S.A. 105, 16882 (2008).
47.Silver, F.H., Ebrahimi, A., Snowhill, P.B., Connect. Tissue Res. 43, 569 (2002).
48.Arora, P.D., Narani, N., McCulloch, C.A., Am. J. Pathol. 154, 871 (1999).
49.Ifkovits, J.L., Burdick, J.A., Tissue Eng. 13, 2369 (2007).
50.Feninat, F.E., Laroche, G., Fiset, M., Mantovani, D., Adv. Eng. Mat. 4, 91 (2002).
51.Maheshwari, G., Brown, G., Lauffenburger, D.A., Wells, A., Griffith, L.G., J. Cell. Sci. 113 (Pt 10), 1677 (2000).
52.Hartgerink, J.D., Beniash, E., Stupp, S.I., Proc. Natl. Acad. Sci. U.S.A. 99, 5133 (2002).
53.Sy, J.C., Klemm, A.S., Shastri, V.P., Adv. Mater. 21, 1814 (2009).
54.Soike, T., Streff, A., Guan, C., Ortega, R., Tantawy, M., Pino, C., Shastri, V.P., Adv. Mater. 22, 1392 (2010).
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

MRS Bulletin
  • ISSN: 0883-7694
  • EISSN: 1938-1425
  • URL: /core/journals/mrs-bulletin
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed