Skip to main content

Nanoparticle–protein interactions: Water is the key

  • Daniel F. Moyano (a1), Moumita Ray (a2) and Vincent M. Rotello (a3)

Nanoparticle (NP) surface properties define how engineered nanomaterials interact with proteins. In aqueous systems, these interactions are driven by the binding of water to NPs and proteins. Understanding the true nature of this NP–water interface and its involvement in the properties of nanomaterials is a fundamental challenge in nanotechnology. Here, we review recent studies on the involvement of water molecules in the interaction of NPs with proteins. We first address the thermodynamic aspects of the NP–protein interaction and the means by which solvation shells can alter the nature of this phenomenon. We then discuss how the chemical nature of the NP surface affects the adsorption of water molecules and how this adsorption can either favor or inhibit protein–NP interactions.

Hide All
1.Niemeyer, C.M., Angew. Chem. Int. Ed. 40, 4128 (2001).
2.Tang, R., Kim, C.S., Solfiell, D.J., Rana, S., Mout, R., Velázquez-Delgado, E.M., Chompoosor, A., Jeong, Y., Yan, B., Zhu, Z.-J., Kim, C., Hardy, J.A., Rotello, V.M., ACS Nano 7, 6667 (2013).
3.Mcnaughton, B.R., Cronican, J.J., Thompson, D.B., Liu, D.R., Proc. Natl. Acad. Sci. U.S.A. 106, 6111 (2009).
4.Jain, K.K., Clin. Chim. Acta 358, 37 (2005).
5.Saha, K., Agasti, S.S., Kim, C., Li, X., Rotello, V.M., Chem. Rev. 112, 2739 (2012).
6.Rana, S., Yeh, Y.-C., Rotello, V.M., Curr. Opin. Chem. Biol. 14, 828 (2010).
7.Walkey, C.D., Chan, W.C.W., Chem. Soc. Rev. 41, 2780 (2012).
8.You, C.-C., De, M., Rotello, V.M., Curr. Opin. Chem. Biol. 9, 639 (2005).
9.De, M., Miranda, O.R., Rana, S., Rotello, V.M., Chem. Commun. 16, 2157 (2009).
10.Moyano, D.F., Rotello, V.M., Langmuir 27, 10376 (2011).
11.You, C.-C., Agasti, S.S., De, M., Knapp, M.J., Rotello, V.M., J. Am. Chem. Soc. 128, 14612 (2006).
12.De, M., You, C.-C., Srivastava, S., Rotello, V.M., J. Am. Chem. Soc. 129, 10747 (2007).
13.Houk, K.N., Leach, A.G., Kim, S.P., Zhang, X., Angew. Chem. Int. Ed. 42, 4872 (2003).
14.You, C.C., De, M., Han, G., Rotello, V.M., J. Am. Chem. Soc. 127, 12873 (2005).
15.Moyano, D.F., Rana, S., Bunz, U.H.F., Rotello, V.M., Faraday Discuss. 152, 33 (2011).
16.Chen, K., Rana, S., Moyano, D.F., Xu, Y., Guo, X., Rotello, V.M., Nanoscale 6, 6492 (2014).
17.Gessner, A., Waicz, R., Lieske, A., Paulke, B.R., Mäder, K., Müller, R.H., Int. J. Pharm. 196, 245 (2000).
18.Ding, H.-M., Ma, Y.-Q., Biomaterials 35, 8703 (2014).
19.Zhu, Z.J., Posati, T., Moyano, D.F., Tang, R., Yan, B., Vachet, R.W., Rotello, V.M., Small 8, 2659 (2012).
20.Shima, F., Akagi, T., Akashi, M., Biomater. Sci. 2, 1419 (2014).
21.Salvati, A., Pitek, A.S., Monopoli, M.P., Prapainop, K., Bombelli, F.B., Hristov, D.R., Kelly, P.M., Aberg, C., Mahon, E., Dawson, K.A., Nat. Nanotechnol. 8, 137 (2013).
22.Aggarwal, P., Hall, J.B., McLeland, C.B., Dobrovolskaia, M.A., McNeil, S.E., Adv. Drug Deliv. Rev. 61, 428 (2009).
23.Jokerst, J.V., Lobovkina, T., Zare, R.N., Gambhir, S.S., Nanomedicine 6, 715 (2011).
24.You, C.-C., De, M., Rotello, V.M., Org. Lett. 7, 5685 (2005).
25.Gombotz, W.R., Guanghui, W., Horbett, T.A., Hoffman, A.S., J. Biomed. Mater. Res. 25, 1547 (1991).
26.Reddy, S.T., van der Vlies, A.J., Simeoni, E., Angeli, V., Randolph, G.J., O’Neil, C.P., Lee, L.K., Swartz, M.A., Hubbell, J.A., Nat. Biotechnol. 25, 1159 (2007).
27.Cao, Z., Jiang, S., Nano Today 7, 404 (2012).
28.Keefe, A.J., Jiang, S., Nat. Chem. 4, 59 (2012).
29.Chen, S., Zheng, J., Li, L., Jiang, S., J. Am. Chem. Soc. 127, 14473 (2005).
30.Moyano, D.F., Saha, K., Prakash, G., Yan, B., Kong, H., Yazdani, M., Rotello, V.M., ACS Nano 8, 6748 (2014).
31.Yang, W., Liu, S., Bai, T., Keefe, A., Zhang, L., Ella-Menye, J.-R., Li, Y., Jiang, S., Nano Today 9, 10 (2014).
32.Arvizo, R.R., Miranda, O.R., Moyano, D.F., Walden, C.A., Giri, K., Bhattacharya, R., Robertson, J.D., Rotello, V.M., Reid, J.M., Mukherjee, P., PLoS One 6, e24374 (2011).
33.Leng, C., Han, X., Shao, Q., Zhu, Y., Li, Y., Jiang, S., Chen, Z., J. Phys. Chem. C 118, 15840 (2014).
34.Shao, Q., Jiang, S., J. Phys. Chem. B 118, 7630 (2014).
35.Pillai, P.P., Huda, S., Kowalczyk, B., Grzybowski, B.A., J. Am. Chem. Soc. 135, 6392 (2013).
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

MRS Bulletin
  • ISSN: 0883-7694
  • EISSN: 1938-1425
  • URL: /core/journals/mrs-bulletin
Please enter your name
Please enter a valid email address
Who would you like to send this to? *



Altmetric attention score

Full text views

Total number of HTML views: 10
Total number of PDF views: 90 *
Loading metrics...

Abstract views

Total abstract views: 257 *
Loading metrics...

* Views captured on Cambridge Core between September 2016 - 17th March 2018. This data will be updated every 24 hours.