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Biocompatible luminescent nanoparticles on the basis of calcium phosphate

Published online by Cambridge University Press:  29 July 2011

Sofia Dembski
Affiliation:
Fraunhofer Institute for Silicate Research ISC, Neunerplatz 2, Wuerzburg, 97082, Germany
Moritz Milde
Affiliation:
Fraunhofer Institute for Silicate Research ISC, Neunerplatz 2, Wuerzburg, 97082, Germany
Emeline Dassonneville
Affiliation:
Fraunhofer Institute for Silicate Research ISC, Neunerplatz 2, Wuerzburg, 97082, Germany
Carsten Gellermann
Affiliation:
Fraunhofer Institute for Silicate Research ISC, Neunerplatz 2, Wuerzburg, 97082, Germany
Torsten Klockenbring
Affiliation:
Fraunhofer Institute for Molecular Biology and Applied Ecology, Forckenbeckstr. 6, Aachen, 52074, Germany
Marcel Dyrba
Affiliation:
Centre for Innovation Competence SiLi-nano®, Martin Luther University of Halle-Wittenberg, Karl-Freiherr-von-Fritsch-Str. 3, Halle (Saale), 06120, Germany
Stefan Schweizer
Affiliation:
Centre for Innovation Competence SiLi-nano®, Martin Luther University of Halle-Wittenberg, Karl-Freiherr-von-Fritsch-Str. 3, Halle (Saale), 06120, Germany Fraunhofer Center for Silicon Photovoltaics, Walter-Hülse-Str. 1, Halle (Saale), 06120, Germany
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Abstract

Luminescent lanthanide doped SiO2/Hydroxylapatite (HAp) core/shell nanoparticles (NPs) were synthesized by sol-gel technology. The resulting NPs exhibited an amorphous SiO2 core and a crystalline luminescent shell. The formation of the HAp layer was possible at pH 8.5. The characterization of the resulting NPs was done by transmission electron microscopy, X-ray diffraction analysis, inductively-coupled plasma combined with optical emission spectrometry, and photoluminescence spectroscopy. Additionally, the newly developed SiO2/HAp:Ln3+ core/shell NPs were tested for their biocompatibility, e. g. by an in vitro cell culture based assay.

Type
Research Article
Copyright
Copyright © Materials Research Society 2011

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