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Bioinspired Artificial Protein Materials: Self-Assembly andOrder from Nano to Macroscale

Published online by Cambridge University Press:  10 March 2011

Min Dai ,
Jennifer S. Haghpanah ,
Carlo Yuvienco  and
Jin Kim Montclare
Min Dai
Affiliation:
Polytechnic Institute of New York University, 6 Metrotech Center, Brooklyn, NY, 11201 U.S.A.
Jennifer S. Haghpanah
Affiliation:
Polytechnic Institute of New York University, 6 Metrotech Center, Brooklyn, NY, 11201 U.S.A.
Carlo Yuvienco
Affiliation:
Polytechnic Institute of New York University, 6 Metrotech Center, Brooklyn, NY, 11201 U.S.A.
Jin Kim Montclare
Affiliation:
Polytechnic Institute of New York University, 6 Metrotech Center, Brooklyn, NY, 11201 U.S.A. SUNY Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY 11203, U.S.A.
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Abstract

We describe the biosynthesis and characterization of protein materialscomprised of two distinct self-assembling domains (SADs): elastin (E) foundin tissue for its elastic properties and cartilage oligomeric matrix proteincoiled-coil (COMPcc, C) predominantly locatedin joint and in bones. Based onearlier studies on protein block polymers comprised these two SADs,orientation and number of blocks play a crucial role in the overallstimuli-responsive supramolecular assembly behavior. Here we fabricate arange of EnC and CEn block polymers in which the Edomain is systematically truncated to explore the effects of the E domain onthe overall physicochemical behavior.

Keywords

biomaterialbiological synthesis (assembly)biomimetic (assembly)

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