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Combinatorial Materials Development using Gradient Arrays. Sphere Covering Lattice Designs: Designs for Efficient use of Experimental Resources.

Published online by Cambridge University Press:  01 February 2011

James N. Cawse
James N. Cawse*
Affiliation:
(GE Corporate Research and Development, 1 Research Circle, Niskayuna NY 12309)
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Abstract

Gradient arrays are now common tools in combinatorial chemistry for discovery of new leads to commercial materials. Although the cost per sample has dropped markedly with new high throughput methods, efficient use of experimental resources is still important. Examination of gradient arrays from an informational standpoint suggests that designs which use the concepts of sphere packing and covering will be more efficient than simple gradients. This is especially true in higher dimensional systems.

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