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Containerless Polymeric Microsphere Production for Biomedical Applications

Published online by Cambridge University Press:  26 February 2011

W. K. Rhim ,
M. T. Hyson ,
S. K. Chung ,
M. Colvin  and
M. Chang
W. K. Rhim
Affiliation:
Jet Propulsion Laboratory California Institute of Technology Pasadena, CA 91109
M. T. Hyson
Affiliation:
Jet Propulsion Laboratory California Institute of Technology Pasadena, CA 91109
S. K. Chung
Affiliation:
Jet Propulsion Laboratory California Institute of Technology Pasadena, CA 91109
M. Colvin
Affiliation:
Jet Propulsion Laboratory California Institute of Technology Pasadena, CA 91109
M. Chang
Affiliation:
Jet Propulsion Laboratory California Institute of Technology Pasadena, CA 91109
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Abstract

A containerless method that produces highly uniform microspheres (> 50 microns in diameter) from many materials has been developed for biomedical applications. A piezoelectrically vibrated drop generator forms uniform (monodisperse) monomer droplets that are either electrostatically levitated and polymerized using UV irradiation, or free radical polymerized. Spheres of 2-hydroxyethyl methacrylate (HEMA) polymer have been produced with diameters of 155 microns ±1.57%.

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