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Continuous Synthesis of Inorganic Magnetic Nanocomposites by Laser Pyrolysis for Biomedical Applications

Published online by Cambridge University Press:  01 February 2011

Sabino Veintemillas ,
Brigitte Bouchet-Fabre ,
Maria Puerto Morales ,
Yann Leconte ,
R Costo ,
Pierre Bonville  and
Nathalie C Herlin-Boime
Sabino Veintemillas
Affiliation:
sabino@icmm.csic.es, ICCM, madrid 28049, Spain
Brigitte Bouchet-Fabre
Affiliation:
brigitte.bouchet-fabre@cea.fr, SPAM/LFP (CEA-CNRS URA 2453), gif sur Yvette, 91191, France, Metropolitan
Maria Puerto Morales
Affiliation:
puerto@icmm.csic.es, ICCM, madrid, 28049, Spain
Yann Leconte
Affiliation:
yann.leconte@cea.fr, SPAM/LFP (CEA-CNRS URA 2453), gif sur Yvette, 91191, France, Metropolitan
R Costo
Affiliation:
R.costo@icmm.es, ICCM, madrid, 28049, Spain
Pierre Bonville
Affiliation:
pierre.bonville@cea.fr, SPEC, gif sur Yvette, 91191, France, Metropolitan
Nathalie C Herlin-Boime
Affiliation:
nathalie.herlin@cea.fr, SPAM/LFP (CEA-CNRS URA 2453), gif sur Yvette, 91191, France, Metropolitan
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Abstract

Nanocomposite particles made from encapsulation of magnetic nanoparticles in an inorganic matrix have a real interest in biomedicine due to their high resistance against biodegradation compared with nanoparticles encapsulated in an organic matrix and little work has been published concerning such materials. In this work we use the laser pyrolysis method for the preparation of magnetic composites of Fe-based nanoparticles dispersed in silica and carbon. The precursor is an aerosol of a precursor which can be easily used in a safe way. Important advantages of the laser pyrolysis method are the reproducibility, simplicity (one step method) and continuity which allows producing significant amounts of nanoparticles. The short reaction times (ms) involved in the nucleation of the powders insure the nanometric particle size of both the magnetic component and the inorganic matrix.

This paper is focused on the synthesis and characterization of the Fe@SiO2 and Fe@C nanopowders generated by laser pyrolysis of ferrocene diluted in toluene and carried to the reaction zone in aerosol form. The silica coating was formed by the addition of tetraethoxysilane (TEOS) to the reactant. The samples were characterized by X-ray diffraction (XRD), infrared spectroscopy (IR), transmission electron microscopy (TEM), specific surface area determination (BET) and magnetic measurements. In the case of Fe@SiO2 the process generates rather homogeneous iron/magnetite particles smaller than 10 nm in diameter surrounded by a SiO2 coating of about 20 nm. In the case Fe@C the process generate iron based magnetic nanoparticles of complex composition smaller than 11 nm surrounded by a graphitic carbon layer of 50 nm. Stable aqueous dispersions at physiological pH were produced for both systems by means of strong oxidation in aqueous solutions, which is a very encouraging result for application in the field of living tissues.

Keywords

laser-induced reactionnanostructuremagnetic properties
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 962: Symposium P – Nanoscale Magnets – Synthesis, Self-Assembly, Properties and Applications , 2006 , 0962-P10-27
Copyright
Copyright © Materials Research Society 2007

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References

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