Skip to main content Accessibility help
×
Home

Combinatorial methods and high-throughput experimentation in synthetic polymer chemistry

Published online by Cambridge University Press:  01 February 2011

Richard Hoogenboom
Affiliation:
Laboratory of Macromolecular Chemistry and Nanoscience, Eindhoven University of Technology and Dutch Polymer Institute (DPI), PO Box 513, 5600 MB Eindhoven, The Netherlands. E-Mail: u.s.schubert@tue.nl; Internet: www.schubert-group.com.
Michael A. R. Meier
Affiliation:
Laboratory of Macromolecular Chemistry and Nanoscience, Eindhoven University of Technology and Dutch Polymer Institute (DPI), PO Box 513, 5600 MB Eindhoven, The Netherlands. E-Mail: u.s.schubert@tue.nl; Internet: www.schubert-group.com.
Ulrich S. Schubert
Affiliation:
Laboratory of Macromolecular Chemistry and Nanoscience, Eindhoven University of Technology and Dutch Polymer Institute (DPI), PO Box 513, 5600 MB Eindhoven, The Netherlands. E-Mail: u.s.schubert@tue.nl; Internet: www.schubert-group.com.
Corresponding
E-mail address:
Get access

Abstract

Combinatorial chemistry has revolutionized the drug discovery as well as the catalyst discovery and optimization process during the last years. Nowadays, triggered by these developments, combinatorial methods and parallel chemistry also emerge in the field of material and polymer chemistry. Especially the field of polymer research seems to be perfectly suited for these approaches since many parameters can be varied during synthesis, processing, blending, formulation and compounding. Moreover, the screening of interesting parameters, such as molecular weight, polydispersity, polymerization kinetics, viscosity, hardness or stiffness, became feasible only recently.

Within this contribution we will describe our strategy to construct a most efficient workflow in the field of combinatorial polymer research. New developments made by our group as well as some general aspects will be discussed.

Type
Research Article
Copyright
Copyright © Materials Research Society 2004

Access options

Get access to the full version of this content by using one of the access options below.

References

1. Jandeleit, B., Schaefer, D. J., Powers, T. S., Turner, H. W., Weinberg, W. H., Angew. Chem. 1999, 111, 26482689; Angew. Chem. Int. Ed. 38, 2494–2532 (1999).3.0.CO;2-N>CrossRefGoogle Scholar
2. Hoogenboom, R., Meier, M. A. R., Schubert, U. S., Macromol. Rapid. Commun. 24, 1532 (2003).CrossRefGoogle Scholar
3. Meier, M. A. R., Hoogenboom, R., Schubert, U. S., Macromol. Rapid. Commun. 25, 2133 (2004).CrossRefGoogle Scholar
4. Williamson, D. T., Long, T. E., Polym. Preprints 42, 643 (2001).Google Scholar
5. Gooding, O. W., Vo, L., Bhattacharyya, S., Labadie, J. W., J. Comb. Chem. 4, 576 (2002).CrossRefGoogle Scholar
6. Flaten, G. R., Walmsley, A. D., Analyst 128, 935 (2003).CrossRefGoogle Scholar
7. Hoogenboom, R., Schubert, U. S., J. Polym. Sci.: Part A: Polym. Chem. 41, 24252434 (2003).CrossRefGoogle Scholar
8. Aoi, K., Okada, M., Prog. Polym. Sci. 21, 151208 (1996).CrossRefGoogle Scholar
9. Hoogenboom, R., Fijten, M. W. M., Meier, M. A. R., Schubert, U. S., Macromol. Rapid Commun. 24, 9297 (2003).CrossRefGoogle Scholar
10. Hoogenboom, R., Fijten, M. W. M., Brändli, C., Schroer, J., Schubert, U. S., Macromol. Rapid Commun. 24, 98103 (2003).CrossRefGoogle Scholar
11. Hoogenboom, R., Fijten, M. W. M., Abeln, C. H., Schubert, U. S., Macromol. Rapid Commun. 25, 237242 (2004).CrossRefGoogle Scholar
12. Hoogenboom, R., Fijten, M. W. M., Abeln, C. H., Schubert, U. S., Polym. Mat. Sci. Eng. 90, (2004) in press.Google Scholar
13. Hoogenboom, R., Fijten, M. W. M., Schubert, U. S., Macromol. Rapid Commun. 25, 339343 (2004).CrossRefGoogle Scholar
14. Hoogenboom, R., Fijten, M. W. M., Schubert, U. S., J. Polym. Sci.: Part A: Polym. Chem. 42, (2004) in press.CrossRefGoogle Scholar
15. Hoogenboom, R., Fijten, M. W. M., Schubert, U. S., Polym. Mat. Sci. Eng., 90, (2004) in press.Google Scholar
16. Wang, J. S., Matyjaszewski, K., J. Am. Chem. Soc. 117, 5614 (1995).CrossRefGoogle Scholar
17. Zhang, H., Fijten, M. W. M., Hoogenboom, R., Reinierkes, R., Schubert, U. S., Macromol. Rapid Commun. 24, 8186 (2003).CrossRefGoogle Scholar
18. Zhang, H., Fijten, M. W. M., Hoogenboom, R., Schubert, U. S., ACS Symp. Ser. 845, 193205 (2003).CrossRefGoogle Scholar
19. Zhang, H., Marin, V., Fijten, M. W. M., Schubert, U. S., J. Polym. Sci.: Part A: Polym. Chem. 42, (2004) in press.Google Scholar
20. Voorn, D.-J., Fijten, M. W. M., Meuldijk, J., Schubert, U. S., van Herk, A. M., Macromol. Rapid. Commun. 24, 320324 (2003).CrossRefGoogle Scholar
21. Schmatloch, S., van den Berg, A. M. J., Schubert, U. S., Macromol. Rapid Commun. 25, 321325 (2004).CrossRefGoogle Scholar
22. Guerrero-Sanchez, C., Schubert, U. S., Polym. Mat. Sci. Eng., 90, (2004) in press.Google Scholar
23. PSS HighSpeed columns, Polymer Standards Service GmbH, 55120 Mainz, Germany, http://www.polymer.de.Google Scholar
24. Meier, M. A. R., Schubert, U. S., Rapid Commun. Mass Spectrom. 17, 713716 (2003).CrossRefGoogle Scholar
25. Meier, M. A. R., Hoogenboom, R., Fijten, M. W. M., Schneider, M., Schubert, U. S., J. Comb. Chem. 5, 369374 (2003).CrossRefGoogle Scholar
26. Meier, M. A. R., de Gans, B. J., van den Berg, A. M. J., Schubert, U. S., Rapid Commun. Mass Spectrom. 17, 23492353 (2003).CrossRefGoogle Scholar
27. de Gans, B. J., Schubert, U. S., Macromol. Rapid Commun. 24, 659666 (2003).CrossRefGoogle Scholar
28. Macromol. Rapid Commun. 23, 643–645 (2002);Google Scholar
Macromol. Rapid Commun. 24, 642–643 (2003).Google Scholar
29. Macromol. Rapid Commun. 24, 3–142 (2003);CrossRefGoogle Scholar
Macromol. Rapid Commun. 25, 3–386 (2004).Google Scholar

Full text views

Full text views reflects PDF downloads, PDFs sent to Google Drive, Dropbox and Kindle and HTML full text views.

Total number of HTML views: 0
Total number of PDF views: 12 *
View data table for this chart

* Views captured on Cambridge Core between September 2016 - 18th January 2021. This data will be updated every 24 hours.

Hostname: page-component-77fc7d77f9-fgqm6 Total loading time: 0.402 Render date: 2021-01-18T04:36:22.036Z Query parameters: { "hasAccess": "0", "openAccess": "0", "isLogged": "0", "lang": "en" } Feature Flags last update: Mon Jan 18 2021 03:55:59 GMT+0000 (Coordinated Universal Time) Feature Flags: { "metrics": true, "metricsAbstractViews": false, "peerReview": true, "crossMark": true, "comments": true, "relatedCommentaries": true, "subject": true, "clr": true, "languageSwitch": true, "figures": false, "newCiteModal": false, "shouldUseShareProductTool": true, "shouldUseHypothesis": true, "isUnsiloEnabled": true }

Send article to Kindle

To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Combinatorial methods and high-throughput experimentation in synthetic polymer chemistry
Available formats
×

Send article to Dropbox

To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

Combinatorial methods and high-throughput experimentation in synthetic polymer chemistry
Available formats
×

Send article to Google Drive

To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

Combinatorial methods and high-throughput experimentation in synthetic polymer chemistry
Available formats
×
×

Reply to: Submit a response


Your details


Conflicting interests

Do you have any conflicting interests? *