Hostname: page-component-588bc86c8c-ttbdn Total loading time: 0 Render date: 2023-11-30T13:17:28.194Z Has data issue: false Feature Flags: { "corePageComponentGetUserInfoFromSharedSession": true, "coreDisableEcommerce": false, "useRatesEcommerce": true } hasContentIssue false

Nanoantibiotic Particles for Shape and Size Recognition of Pathogens

Published online by Cambridge University Press:  14 January 2013

Josef Borovicka
Department of Chemistry, University of Hull, Hull, HU6 7RX, UK
Simeon D. Stoyanov
Unilever R&D, Olivier van Noortlaan 120, 3133 AT Vlaardingen, the Netherlands.
Vesselin N. Paunov*
Department of Chemistry, University of Hull, Hull, HU6 7RX, UK
*Corresponding author. Email:, Phone : +44 1482 465660, Fax : +44 1482 466410.
Get access


We have developed a novel class of colloidal particles capable of shape and size recognition as well as specific binding to the target cells. These colloid particles were fabricated using a nanoimprinting technology which yields inorganic imprints of the chosen target microorganisms. The products of the templating process are partially fragmented inorganic shells which can selectively bind to their biological counterparts, therefore impairing microbial cell growth, replication and infection. We have named this class of particles, which are capable of selectively recognizing bacterial shape and size, “nanoantibiotics”, which can be further functionalized to kill the target cells. The selective binding is driven by the increased area of contact upon recognition of the cell shape and size between the cells and their matching inorganic shell fragments. Here, we demonstrate the cell recognition and binding action of such particles using two different microbial test organisms.

Copyright © Materials Research Society 2013 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)



Arias, C. A., Murray, B. E., N. Engl. J. Med. 2009, 360, 439443.CrossRefGoogle Scholar
Abbanat, D., Macielag, M., Bush, K., Expert Opin. Investig. Drugs, 2003, 12, 379399.CrossRefGoogle Scholar
Li, P., Li, J., Wu, C., Wu, Q., Li, J., Nanotechnology, 2005, 16, 19121917.CrossRefGoogle Scholar
Choi, H.J., Han, S.W., Lee, S.J., Kim, K., J. Colloid Interf. Sci., 2003, 264, 458–66.CrossRefGoogle Scholar
Shrivastava, S., Bera, T., Roy, A., Singh, G., Ramachandrarao, P., Dash, D., Nanotechnology, 2007, 18, 225103.1-9.CrossRefGoogle Scholar
Martinez-Gutierrez, F., Olive, P. L., Banuelos, A., Orrantia, E., Nino, N., Sanchez, E. M., Ruiz, F., Bach, H., Av-Gay, Y., Nanomedicine: Nanotechnology, Biology, and Medicine, 2010, 6, 681688.CrossRefGoogle Scholar
Dickert, F. L., Hayden, O., Anal. Chem. 2002, 74, 13021306.CrossRefGoogle Scholar
Cohen, T., Starosvetsky, J., Cheruti, U., Armon, R., Int. J. of Mol. Sci. 2010, 11, 12361252.CrossRefGoogle Scholar
Harvey, S., Mong, G., Ozanich, R., McLean, J., Goodwin, S., Valentine, N., Fredrickson, J., Anal. and Bioanal. Chem., 2006, 386, 211219.CrossRefGoogle Scholar
Weinzierl, D., Lind, A., Kunz, W., Crystal Growth & Design, 2009, 9, 23182323.CrossRefGoogle Scholar