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Analytical and Structural Electron Microscopy of Metal-Cell Interactions.

Published online by Cambridge University Press:  26 February 2011

Neil A. Coombs ,
Robert M. Pilliar  and
George C. Weatherly
Neil A. Coombs
Affiliation:
Dept. of Metallurgy and Materials Science, University of Toronto, 184 College Street, Toronto, Canada M5S 1A4.
Robert M. Pilliar
Affiliation:
Dept. of Metallurgy and Materials Science, University of Toronto, 184 College Street, Toronto, Canada M5S 1A4.
George C. Weatherly
Affiliation:
Dept. of Metallurgy and Materials Science, University of Toronto, 184 College Street, Toronto, Canada M5S 1A4.
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Abstract

Human gingival fibroblasts have been grown in culture on thin (10–50nm) substrates of nickel, chromium and titanium and examined by structural and analytical transmission electron microscopy. Cells grown on titanium show no signs of metal uptake and have morphologies very similar to controls grown on carbon substrates. However, cells grown on nickel and chromium show significant metal uptake and some structural abnormalities. The majority of the ingested nickel and chromium appears to be associated with nucleic acids.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 110: Symposium M – Biomedical Materials and Devices , 1987 , 349
Copyright
Copyright © Materials Research Society 1988

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