Skip to main content Accessibility help

Biomimetic Spinning of Recombinant Silk Proteins

  • David Keerl (a1), John George Hardy (a2) and Thomas Scheibel (a3)


In the past, we have successfully designed and produced a variety of engineered spider silk-like proteins (eADF3 and eADF4) based upon the primary sequence of the natural dragline proteins ADF3 and ADF4 from the spider Araneus diadematus [1]. Genetically engineered spider silk proteins can be modified at the molecular level to optimize the biochemical and mechanical properties of the final product. Although engineered spider silk proteins can be processed into fibers using different spinning methods, our group is interested in the technical realization of a biomimetic approach. Here, we present an overview over our biomimetic fiber production process.



Hide All
[1] Huemmerich, D. Helsen, C. W. Quedzuweit, S. Oschmann, J. Rudolph, R. Scheibel, T. Biochemistry 2004, 43, 1360413612.
[2] Heim, M. Keerl, D. Scheibel, T. Angewandte Chemie-International Edition 2009, 48, 35843596.
[3] Gerritsen, V. B. Protein Spotlight 2002, 24, 12.
[4] Vollrath, F. J Biotechnol 2000, 74, 6783.
[5] Romer, L. Scheibel, T. in Fibrous Proteins (Ed.: Scheibel, T.), Landes Bioscience, Austin, 2008.
[6] Scheibel, T. Microb Cell Fact 2004, 3, 14.
[7] Vollrath, F. Knight, D. P. Nature 2001, 410, 541548.
[8] Work, R. W. Textile Research Journal 1976, 46, 485492.
[9] Fox, L. R. Annual Review of Ecology and Systematics 1975, 6, 87106.
[10] Vendrely, C. Scheibel, T. Macromol Biosci 2007, 7, 401409.
[11] Karatzas, C. N. Turner, J. D. Karatzas, A.L. 1999
[12] Schmidt, M. Romer, L. Strehle, M. Scheibel, T. Biotechnology Letters 2007, 29, 17411744.
[13] Vollrath, F. Knight, D. P. Hu, X. W. Proc. R. Soc. Lond., Ser. B: Biol. Sci. 1998, 265, 817820.
[14] Vollrath, F. Knight, D. P. Int. J. Biol. Macromol. 1999, 24, 243249.
[15] Lazaris, A. Arcidiacono, S. Huang, Y. Zhou, J. F. Duguay, F. Chretien, N. Welsh, E. A. Soares, J. W. Karatzas, C. N. Science 2002, 295, 472476.
[16] Viney, C. in Structural Biological Materials: Design and Structure-Property Relationships, Vol. 10 (Ed.: Elices, M.), American Chemical Society, Washington D.C., 2000, pp. 295333.
[17] Viney, C. Huber, A. E. Dunaway, D. L. Kerkam, K. Case, S. T. in Silk Polymers. Materials Science and Biotechnology (Eds.: Kaplan, D. L. Adams, W. W. Farmer, B. Viney, C.), American Chemical Society, Washington D.C., 1994, pp. 120136.
[18] Rammensee, S. Slotta, U. Scheibel, T. Bausch, A. R. Proceedings of the National Academy of Sciences of the United States of America 2008, 105, 65906595.
[19] Slotta, U. Rammensee, S. Gorb, S. Scheibel, T. Angewandte Chemie-International Edition 2008, 47.
[20] Vollrath, F. Knight, D. P. WO 01/38614 A1, 1999
[21] Scheibel, T. Hummerich, D. (Technische Universitaet Muenchen), WO 2007/031301 A3, 2007
[22] Exler, J. H. Hummerich, D. Scheibel, T. Angewandte Chemie-International Edition 2007, 46, 35593562.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

MRS Online Proceedings Library (OPL)
  • ISSN: -
  • EISSN: 1946-4274
  • URL: /core/journals/mrs-online-proceedings-library-archive
Please enter your name
Please enter a valid email address
Who would you like to send this to? *



Altmetric attention score

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed