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Biomolecular material systems with encapsulated interfacebilayers

Published online by Cambridge University Press:  28 January 2011

Stephen A. Sarles  and
Donald J. Leo
Stephen A. Sarles
Affiliation:
Center for Intelligent Material Systems and Structures, 310 Durham Hall, Dept. of Mechanical Engineering, Virginia Tech, Blacksburg, VA 24061, U.S.A.
Donald J. Leo
Affiliation:
Center for Intelligent Material Systems and Structures, 310 Durham Hall, Dept. of Mechanical Engineering, Virginia Tech, Blacksburg, VA 24061, U.S.A.
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Abstract

In this paper we present a novel approach for interface bilayer formation inwhich the uptake of an aqueous lipid vesicle solution by two polymerichydrogels contained in a substrate causes the gels to swell so as to comeinto contact within an internal oil-filled region of the device. Aninterface bilayer, similar to those formed using the droplet interfacebilayer (DIB) method, forms upon contact in oil between the lipid-encasedends of the two gels. Experimental measurements provide initial evidencethat gel swelling enables automatic bilayer formation within a few minutesafter the addition of lipid solution. The approach presented herein workstoward the development of a new portable, easy-to-use screening platformthat features tailored interface bilayers for a wide variety of screeningapplications.

Keywords

biomimetic (assembly)surface chemistryself-assembly

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