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Calcium Phosphate Cements: Chemistry, Properties, and Applications

  • Laurence C. Chow (a1)

This paper reviews recent studies on self-setting calcium phosphate cements (CPC). Discussions are focused on the cement setting reactions, the products formed, those properties of the cements that contribute to their clinical efficacy, and areas of future improvements that could make CPC useful in a wider range of applications. The strengths of CPC are considerably lower than ceramic calcium phosphate biomaterials and are also lower than some of the dental cements. On the other hand, the combination of self-setting capability and high biocompatibility makes CPC a unique biomaterial. Near perfect adaptation of the cement to the tissue surfaces in a defect, and a gradual resorption followed by new bone formation are some of the distinctive advantages of CPC. In its present state CPC appears to be suitable for a number of applications. Much remains to be done to further improve its properties to meet the requirements for different applications.

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5. L C Chow : Development of Self-setting Calcium Phosphate Cements. J Ceramic Soc Japan, 99:954964, 1991.

6. Y Fukase , E D Eanes , S Takagi , L C Chow , W E Brown : Setting Reactions and Compressive Strengths of Calcium Phosphate Cements. J Dent Res 69, 18521856, 1990.

11. S Takagi , L C Chow , K Ishikawa : Formation of Hydroxyapatite in New Calcium Phosphate Cements, Biomaterials 19:15931599, 1998.

12. A Sugawara , L C Chow , S Takagi , H Chohayeb : In vitro Evaluation of the Sealing Ability of a Calcium Phosphate Cement When Used as a Root Canal Sealer-Filler. J Endodon 16, 162165, 1990.

14. P D Costantino , C D Friedman , K Jones , L C Chow , G A Sisson : Experimental Hydroxyapatite Cement Cranioplasty. Plas. Reconstr Surg, 90:174191, 1992.

15. C D Friedman , P D Costantino , K Jones , L C Chow , H J Pelzer , G A Sisson : Hydroxyapatite Cement I I. Obliteration and Reconstruction of The Cat Frontal Sinus. Arch Otolaryngol Head Neck Surg, 117, 385389, 1991.

16. Y C Hong , J T Wang , C Y Hong , W E Brown , L C Chow : The Periapical Tissue Reactions to A Calcium Phosphate Cement in The Teeth of Monkeys. J Biomed Mater Res 25, 485498, 1991.

18. M L Shindo , P D Costantino , C D Friedman , L C Chow : Facial Skeletal Augmentation Using Hydroxyapatite Cement. Arch Otolaryngol Head Neck Surg 119:185190, 1993.

19. A Sugawara , M Nishiyama , K Kusama , I Moro , S Nishimura , I Kudo , L C Chow , S Takagi : Histopathological Reaction of Calcium Phosphate Cement. Dent Mater J, 11, 1116, 1992.

23. A Cherng , S Takagi , L C Chow : Effects of Hydroxypropyl Methylcellulose and Other Gelling Agents on the Handling Properties of Calcium Phosphate Cement. J Biomed Mater Res 35:273277, 1997.

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42. S Matsuya , S Takagi , L C Chow : Hydrolysis of Tetracalcium Phosphate in H3PO4 and KH2PO4. J Mater Sci 31:32633269, 1996.

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  • EISSN: 1946-4274
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