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Catechol-hydrazone conjugates for the rapid functionalization of magnetite nanoparticles with cell targeting groups

Published online by Cambridge University Press:  09 May 2014

Thomas Coxon ,
Andrew Almond ,
Julie E. Gough  and
Simon J. Webb
Thomas Coxon
Affiliation:
School of Chemistry, The University of Manchester, Manchester M13 9PL, UK. MIB, The University of Manchester, 131 Princess Street, Manchester M1 7DN, UK
Andrew Almond
Affiliation:
MIB, The University of Manchester, 131 Princess Street, Manchester M1 7DN, UK
Julie E. Gough
Affiliation:
School of Materials, The University of Manchester, Manchester M1 7HS, UK
Simon J. Webb
Affiliation:
School of Chemistry, The University of Manchester, Manchester M13 9PL, UK. MIB, The University of Manchester, 131 Princess Street, Manchester M1 7DN, UK
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Abstract

The condensation of hydrazides with aldehydes has been found to be a simple and rapid method for synthesizing catechol-terminated coating reagents for magnetite nanoparticles. This approach allowed the production of biotin- and polyethylene glycol-functionalized nanoparticles, whose interaction with 3T3 fibroblast cells has been assessed. The cellular location of these nanoparticles was imaged by fluorescence microscopy, which was made possible by co-coating with a porphyrin-catechol conjugate. Images show significant interactions between biotinylated nanoparticles and 3T3 fibroblasts, but those with a polyethylene glycol coating did not interact.

Keywords

chemical synthesisnanostructurebiomaterial

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Type
Articles
Information
MRS Online Proceedings Library (OPL) , Volume 1688: Symposium Y – Advanced Materials in Extreme Environments , 2014 , mrss14-1688-y08-13
Copyright
Copyright © Materials Research Society 2014 

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