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A Comparative Analysis of Iridium Oxide Nanowires in Electrical Detection of Biochemical Reactions

Published online by Cambridge University Press:  01 February 2011

Vinu Venkatraman ,
Ravikiran Reddy ,
Fengyan Zhang ,
David Evans ,
Sheng-Teng Hsu ,
Bruce Ulrich  and
Shalini Prasad
Vinu Venkatraman
Affiliation:
vinu@pdx.edu, Portland State University, Electrical and Computer Engineering, 1900 SW 4th Ave, Suite 160, Portland, OR, 97201, United States, 5412211243
Ravikiran Reddy
Affiliation:
ravikk@pdx.edu, Portland State University, Electrical and Computer Engineering, 1900 SW 4th Ave, Suite 160, Portland, OR, 97201, United States
Fengyan Zhang
Affiliation:
Fzhang@sharplabs.com, Sharp Labs of America Inc., Camas, WA, 98607, United States
David Evans
Affiliation:
DEvans@sharplabs.com, Sharp Labs of America Inc., Camas, WA, 98607, United States
Sheng-Teng Hsu
Affiliation:
shsu@sharplabs.com, Sharp Labs of America Inc., Camas, WA, 98607, United States
Bruce Ulrich
Affiliation:
bulrich@sharplabs.com, Sharp Labs of America Inc., Camas, WA, 98607, United States
Shalini Prasad
Affiliation:
sprasad@pdx.edu, Portland State University, Electrical and Computer Engineering, 1900 SW 4th Ave, Suite 160, Portland, OR, 97201, United States
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Abstract

Pt, Ir, Au and few other precious metals have highly conducive electrical and chemical properties; hence have been widely used in pH sensors and bimolecular sensing applications. The chief objective of this research is to highlight and demonstrate the advantages that Iridium Oxide (IrOx) nanowires offer over these competing metals in improving the performance metrics of biomolecular sensing. Iridium oxide has very good conductivity and very high charge storing capacity, and hence has an ability to detect very small changes in the surface charge. Nanowires have an ideal morphology to crowd protein molecules and highly increase the surface area of interaction. Higher area of interaction along with iridium oxide's high intrinsic physical adsorption rate, strongly enhance the rate of immobilization of biomolecules and hence enabling high sensitivity detection. Inflammatory protein, C-Reactive protein (CRP) that is a biomarker for cardiovascular disease was used as the model biomolecule for this study.

Keywords

nanostructurebiomedicalelectrical properties
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1095: Symposium EE – Responsive Biomaterials for Biomedical Applications , 2008 , 1095-EE08-22
Copyright
Copyright © Materials Research Society 2008

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References

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