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Development of novel bioelectrocatalytic platform based on in situ generated gold nanoparticles for biomedicalapplications

Published online by Cambridge University Press:  06 March 2012

Prem C. Pandey  and
Dheeraj S. Chauhan
Prem C. Pandey
Affiliation:
Department of Applied Chemistry, Institute of Technology, Banaras Hindu University, Varanasi- 221005, India.
Dheeraj S. Chauhan
Affiliation:
Department of Applied Chemistry, Institute of Technology, Banaras Hindu University, Varanasi- 221005, India.
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Abstract

Gold nanoparticles (AuNp) formed using alkoxysilane precursors are utilizedin the development of thin organically modified silicates (ormosil) films.The resulting films are optically transparent thereby retaining the opticalproperties of AuNp. Surface morphology shows that the in situ generated AuNp retained their nanogeometry in the ormosilfilms. An application of the AuNp encapsulated ormosils is shown inelectrocatalytic determination of hydrogen peroxide. For this purpose,potassium ferricyanide is chosen as electron transfer mediator and isencapsulated in the films. Results show that the presence of AuNp in theormosil matrix dramatically improves the electrochemical behavior ofpotassium ferricyanide. The ormosil films are utilized for electrocatalyticdetermination of hydrogen peroxide. In order to investigate thebiocompatibility of the ormosil film, horseradish peroxidase (HRP) isincorporated resulting in improvement in oxidation and reduction ofperoxide.

Keywords

sensorcatalyticnanostructure

Information

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1418: Symposium LL/MM – Gels and Biomedical Materials , 2012 , mrsf11-1418-mm11-10
Copyright
Copyright © Materials Research Society 2012

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