Hostname: page-component-76fb5796d-vfjqv Total loading time: 0 Render date: 2024-04-26T00:36:56.303Z Has data issue: false hasContentIssue false
  • English
  • Français

Drug Delivery Systems Based on Hydroxyapaptite-coated Poly(lactic-co-glycolic acid) Microspheres

Published online by Cambridge University Press:  01 February 2011

Qingguo Xu  and
Jan T Czernuszka
Qingguo Xu
Affiliation:
qingguo.xu@materials.ox.ac.uk, University of Oxford, Department of Materials, Parks Road, Oxford, OX1 3PH, United Kingdom, +44-1865-273714, +44-1865-273789
Jan T Czernuszka
Affiliation:
jan.czernuszka@materials.ox.ac.uk, University of Oxford, Department of Materials, Parks Road, Oxford, OX1 3PH, United Kingdom
Get access

Abstract

Negatively charged poly(lactic-co-glycolic acid) (PLGA) microspheres were prepared by the solid-in-oil-in-water (s/o/w) method using the anionic surfactant, sodium dodecyl sulfate (SDS), and a hydrophilic antibiotic (amoxicillin) was encapsulated with an encapsulation efficiency of 40.6%. A layer of hydroxyapatite (HA) was coated on these negatively charged PLGA microspheres by a dual constant composition method in 3 - 6 hours. The HA-coated PLGA microspheres (HPLG) had a core-shell structure and were characterised by scanning electron microscopy, focused ion beam microscopy, energy-dispersive X-ray spectrometry, X-ray diffraction and Fourier transform infrared spectroscopy. Sustained release of amoxicillin from HPLG for at least 31 days was shown from in-vitro drug release experiments. A typical triphasic drug release profile had been observed for PLGA and HPLG microspheres. This device exhibited two desirable properties: the sustained release from PLGA and osteoconductivity from HA. Hence, it could have potential applications in delivering drugs to treat bone disorders or infections.

Keywords

biomaterialpolymercoating
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1063: Symposium OO – Solids at the Biological Interface , 2007 , 1063-OO05-08
Copyright
Copyright © Materials Research Society 2008

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

[1] Joosten, U., Joist, A., Frebel, T., Brandt, B., Diederichs, S., Eiff, C. von, Biomaterials 25, 4287 (2004).Google Scholar
[2] Garvin, K., Feschuk, C., Clin. Orthop. Rel. Res. 437, 105 (2005).Google Scholar
[3] Matsumoto, T., Okazaki, M., Inoue, M., Yamaguchi, S., Kusunose, T., Toyonaga, T., Hamada, Y., Takahashi, J., Biomaterials 25, 3807 (2004).Google Scholar
[4] Stigter, M., Bezemer, J., Groot, K. de, Layrolle, P., J. Control. Release 99 (2004) 127–137.Google Scholar
[5] Freiberg, S., Zhu, X., Int. J. Pharm. 282, 1 (2004).Google Scholar
[6] Sinha, V.R., Trehan, A., J. Control. Release 90, 261 (2003)-280.Google Scholar
[7] Lamprecht, A., Torres, H.R., Schafer, U., Lehr, C.M., J. Control. Release 69, 445 (2000).Google Scholar
[8] Xu, Q., Tanaka, Y., Czernuszka, J.T., Biomaterials 28 (2007) 2687–2694.Google Scholar
[9] Kawai, T., Ohtsuki, C., Kamitakahara, M., Miyazaki, T., Tanihara, M., Sakaguchi, Y., Konagaya, S., Biomaterials 25, 4529 (2004).Google Scholar
[10] Wong, A.T.C., Czernuszka, J.T., Colloid Surf. A-Physicochem. Eng. Asp. 78, 245 (1993).Google Scholar