Skip to main content
×
Home
    • Aa
    • Aa

Effects of Growth Factor Presence on Mineralization of Porous Poly(Lactide-Co-Glycolide) Scaffolds In Vitro

  • William L. Murphy (a1), Katherine A. Gilhool (a2), David H. Kohn (a1) (a3) and David J. Mooney (a1) (a3)
Abstract
Abstract

Basic design requirements of scaffolds for bone tissue engineering applications include biocompatibility, temporally controlled degradability, osteoconductivity, mechanical integrity, and mass transport capabilities. A recent study has attempted to meet design criteria via the growth of a carbonated apatite (bone-like) mineral on the inner pore surfaces of a highly porous 85:15 poly(lactide-co-glycolide) scaffold using a biomimetic process. It has also been recently demonstrated that the mineralization strategy can be combined with sustained growth factor delivery to induce vascular tissue ingrowth. The present study examines the effect of protein presence on the mineralization process by measuring the amount of protein incorporated into the scaffold during the process of mineral formation. Surprisingly, vascular endothelial growth factor incorporates more readily into control scaffolds than into scaffolds subjected to mineralization treatment. This finding suggests that there is little incorporation of protein into the growing mineral film, and offers insight into the mechanism for sustained drug delivery from the mineralized scaffolds.

Copyright
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

3 A.G. Mikos and A.J. Thorsen , Polymer 35,1068 (1994).

4 L.D. Harris , B.S. Kim , D.J. Mooney , J. Biomed. Mat. Res. 42, 396 (1998).

6 Y Abe , T Kokubo , T. Yamamuro Apatite coating on ceramics, metals, and polymers utilizing a biological process. J. Mater Sci Mater Med 1,233 (1990).

7 P. Li , K. Nakanishi , T. Kokubo , K. deGroot . Induction and morphology of hydroxyapatite, precipitated from metastable simulated body fluids on sol-gel prepared silica. Biomaterials 14,963 (1993)

8 L.L. Hench , J. Am. Ceram. Soc. 74,1487 (1991).

9 K. Whang , D.C. Tsai , E.K. Nam , M. Aitken , S.M. Sprague , P.K. Patel , K.E. Healy , J Biomed Mater Res 42,491 (1998).

10 D.L. Wheeler , D.L. Chamberland , J.M. Schmitt , D.C. Buck , J.H. Brekke , J.O. Hollinger , S. Joh , K. Sub , J. Biomed. Mat. Res. 43,365 (1998).

15 K.J. Pekarek , J.S. Jacob , E. Mathiowitz , Nature 367,258 (1994).

16 M.R. Kreitz , W.L. Webber , P.M. Galetti , E. Mathiowitz , Biomaterials 18,597 (1997).

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

MRS Online Proceedings Library (OPL)
  • ISSN: -
  • EISSN: 1946-4274
  • URL: /core/journals/mrs-online-proceedings-library-archive
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 2 *
Loading metrics...

Abstract views

Total abstract views: 30 *
Loading metrics...

* Views captured on Cambridge Core between September 2016 - 29th May 2017. This data will be updated every 24 hours.