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Escape Depth of Gold Ions in Tissue Sections

Published online by Cambridge University Press:  10 July 2015

Yasuro Niidome ,
Masanori Fujii ,
Naotoshi Nakashima  and
Takuro Niidome
Yasuro Niidome
Affiliation:
Department of Applied Chemistry, Faculty of Engineering, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan World Premier International (WPI) Research Center, International Institute for Carbon-Neutral Energy Research (I2CNER), Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan
Masanori Fujii
Affiliation:
Department of Applied Chemistry, Faculty of Engineering, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan
Naotoshi Nakashima
Affiliation:
Department of Applied Chemistry, Faculty of Engineering, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan World Premier International (WPI) Research Center, International Institute for Carbon-Neutral Energy Research (I2CNER), Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan
Takuro Niidome
Affiliation:
Department of Applied Chemistry and Biochemistry, Graduate School of Science and Technology, Kumamoto University, 2-39-1 Kurokami, Chuo-ku, Kumamoto 860-8555, Japan. JST-CREST, 5 Sanbancho, Chiyoda-ku, Tokyo 102-0075, Japan
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Abstract

Desorption of gold ions from liver tissue sections, in which intravenously injected gold nanorods were accumulated, were studied to evaluate properties of gold nanorods as a "mass-tag". Gold ions were sensitively detected by using a conventional MALDI-MS machine. When 50-µm-thick blank sections without gold nanorods were placed on or beneath a sample section, desorption of gold ions was almost suppressed. It was found that the escape depth of gold ions from liver tissue sections was less than 50 µm. It was found that we do not have to take account of the escape depth of gold ions if a section were sliced into 10-20 µm thickness.

Keywords

Aumass spectroscopybiomedical

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Articles
Information
MRS Online Proceedings Library (OPL) , Volume 1719: Symposium C – Medical Applications of Noble Metal Nanoparticles (NMNPs) , 2015 , mrsf14-1719-c06-07
Copyright
Copyright © Materials Research Society 2015 

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