Skip to main content

Mechanical and Microstructural Properties of Stratum Corneum

  • Kenneth S. Wu (a1), William W. Van Osdol (a2) and Reinhold H. Dauskardt (a3)

A mechanics approach is presented to study the intercellular delamination resistance and mechanical behavior of stratum corneum (SC) tissue in the direction normal to the skin surface. The effects of temperature and hydration on debonding behavior were also explored. Such understanding, which includes the relationship of mechanical behavior to the underlying SC cellular structure, is essential for emerging transdermal drug delivery technologies. Fracture mechanics-based cantilever-beam specimens were used to determine reproducibly the energy release rates to quantify the cohesive strength of human SC. The debond resistance of fully hydrated SC was found to decrease with increasing temperature, while dehydrated SC exhibited a more complex variation with temperature. Stress-separation tests showed that fracture energies and peak separation stresses decreased with increasing temperature and hydration, although the SC modulus varied only marginally with temperature and hydration. Results are described in terms of microstructural changes associated with hydrophilic regions and intercellular lipid phase transitions.

Hide All
1. Thody A.J. and Friedmann P.S. in Scientific Basis of Dermatology: A Physiological Approach, edited by Thody A.J. and Friedmann P.S. (Churchill Livingstone, Inc., London, 1986), p. 15.
2. Wilkes G.L. and Wildnauer R.H., Biochimica et Biophysica Acta 304, 276 (1973).
3. Papir Y.S., Hsu K.-H., and Wildnauer R.H., Biochimica et Biophysica Acta 399, 170 (1975).
4. Wildnauer R.H., Bothwell J.W., and Douglass A.B., The Journal of Investigative Dermatology 56, 72 (1971).
5. Koutroupi K.S. and Barbenel J.C., Journal of Biomechanics 23, 281 (1990).
6. Nicolopoulos C.S., Giannoudis P.V., Glaros K.D., and Barbenel J.C., Archives of Dermatological Research 290, 638 (1998).
7. Wolfram M.A., Wolejsza N.F., and Laden K., The Journal of Investigative Dermatology 59, 421 (1973).
8. Taub M. B. and Dauskardt R. H. in Biomaterials for Drug Delivery and Tissue Engineering, edited by Mallapragada S., Korsmeyer R., Mathiowitz E., Narasimhan B., and Tracy M., (Mater. Res. Soc. Proc. 662, Warrendale, PA, 2001) pp. NN4.9–NN4.9.6.
9. Ohashi K.L., Romero A.C., McGowan P.D., Maloney W.J., and Dauskardt R.H., J. Ortho. Res., 16, 705 (1998).
10. Elias P.M., Grayson S., Lampe M.A., Williams M.L., and Brown B.E. in Stratum Corneum, edited by Marks R. and Plewig G. (Springer-Verlag, Berlin, 1983), p. 5367.
11. Wilkes G.L., Nguyen A.-L., and Wildnauer R., Biochimica et Biophysica Acta 304, 267 (1973).
12. Vičanová J., Mommaas A.M., Mulder A.A., Koerten H.K., and Ponec M., Cell Tissue Research 286, 115 (1996).
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

MRS Online Proceedings Library (OPL)
  • ISSN: -
  • EISSN: 1946-4274
  • URL: /core/journals/mrs-online-proceedings-library-archive
Please enter your name
Please enter a valid email address
Who would you like to send this to? *


Full text views

Total number of HTML views: 0
Total number of PDF views: 4 *
Loading metrics...

Abstract views

Total abstract views: 47 *
Loading metrics...

* Views captured on Cambridge Core between September 2016 - 24th November 2017. This data will be updated every 24 hours.