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Modified Nanodiamonds for Adsorption of Propidium Iodide and Aflatoxin

Published online by Cambridge University Press:  31 January 2011

Natalie Gibson ,
Tizy-Jiun Mark Luo ,
Olga Shenderova ,
Yong-Jae Choi  and
Donald W Brenner
Natalie Gibson
Affiliation:
nmgibson@ncsu.edu, North Carolina State University, Materials Science and Engineering, Raleigh, North Carolina, United States
Tizy-Jiun Mark Luo
Affiliation:
tluo@ncsu.edu, North Carolina State University, Materials Science and Engineering, Raleigh, North Carolina, United States
Olga Shenderova
Affiliation:
oshenderova@itc-inc.org, International Technology Center, Research Triangle Park, North Carolina, United States
Yong-Jae Choi
Affiliation:
ychoi2@ncsu.edu, North Carolina State University, Materials Science and Engineering, Raleigh, North Carolina, United States
Donald W Brenner
Affiliation:
brenner@ncsu.edu, North Carolina State University, Materials Science and Engineering, Raleigh, North Carolina, United States
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Abstract

Nanodiamonds (NDs) have desirable chemical, physical and biological properties that lend them to a wide range of applications. ND’s facile surface chemistry, for example, can be used to create a high affinity for adsorbing various biological molecules. However, NDs, which are commercially available from multiple vendors, show inconsistencies with surface groups, aggregate sizes and impurity contents that may limit adsorption. We explore adsorption mechanisms of molecules to NDs in efforts to expand ND applications to drug delivery agents, bio-labels and enterosorbents. In doing so, several types of NDs and modification methods are evaluated to increase adsorption capacity and selectivity of propidium iodide and aflatoxin B1. Capacities and binding strengths of target molecules are assessed by Langmuir isotherms and transform calculations. UV-Vis spectroscopy shows our modification treatments are successful in increasing ND adsorption capacities. Additionally, cyclic voltammetry measurements, used to monitor in-situ adsorption, show electrochemical detection even after binding.

Keywords

adsorptionnanoscalediamond
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1236: Symposium SS – Biosurfaces and Biointerfaces , 2009 , 1236-SS09-05
Copyright
Copyright © Materials Research Society 2010

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