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Nano- and Micro-Scale Adhesion in Drug-eluting Stents

Published online by Cambridge University Press:  31 January 2011

Ting Tan
Affiliation:
tingtan@princeton.edu, Princeton University, Princeton, United States
Juan Meng
Affiliation:
jmeng@princeton.edu, Princeton University, princeton, United States
Nima Rahbar
Affiliation:
nrahbar@umassd.edu, Univ of Massachusetts Dartmouth, Boston, United States
Hannah Li
Affiliation:
QLi35@its.jnj.com, Cordis Company, Warren, United States
George Papandreou
Affiliation:
Gpapand2@its.jnj.com, Cordis Company, Warren, United States
Cynthia Maryanoff
Affiliation:
CMARYANO@its.jnj.com, Cordis Company, Spring House, United States
Winston oluwole Soboyejo
Affiliation:
soboyejo@princeton.edusoboyejo@aol.com, Princeton University, Olden Street, Princeton, New Jersey, 08544, United States
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Abstract

This paper presents a combined experimental and theoretical/computational study of adhesion and interfacial fracture between multilayers in a CYPHER® model drug eluting stents (DES). Atomic Force Microscopy (AFM) is used to obtain pull-off forces between coated AFM tips and substrates that simulate the bimaterial surfaces in the DES. Adhesion theories and fracture mechanics concepts are then applied to obtain estimates of the fracture toughness over a range of mode mixities between pure mode I and pure mode II. The trends in the estimates are shown to be in good agreement with experimental measurements of interfacial fracture toughness obtained from Brazil disk specimens over the same range of mode mixities.

Type
Research Article
Copyright
Copyright © Materials Research Society 2010

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