Skip to main content Accessibility help

Nanoantibiotic Particles for Shape and Size Recognition of Pathogens

  • Josef Borovicka (a1), Simeon D. Stoyanov (a2) and Vesselin N. Paunov (a1)

We have developed a novel class of colloidal particles capable of shape and size recognition as well as specific binding to the target cells. These colloid particles were fabricated using a nanoimprinting technology which yields inorganic imprints of the chosen target microorganisms. The products of the templating process are partially fragmented inorganic shells which can selectively bind to their biological counterparts, therefore impairing microbial cell growth, replication and infection. We have named this class of particles, which are capable of selectively recognizing bacterial shape and size, “nanoantibiotics”, which can be further functionalized to kill the target cells. The selective binding is driven by the increased area of contact upon recognition of the cell shape and size between the cells and their matching inorganic shell fragments. Here, we demonstrate the cell recognition and binding action of such particles using two different microbial test organisms.

Corresponding author
*Corresponding author. Email:, Phone : +44 1482 465660, Fax : +44 1482 466410.
Hide All
1. Arias, C. A., Murray, B. E., N. Engl. J. Med. 2009, 360, 439443.
2. Abbanat, D., Macielag, M., Bush, K., Expert Opin. Investig. Drugs, 2003, 12, 379399.
3. Li, P., Li, J., Wu, C., Wu, Q., Li, J., Nanotechnology, 2005, 16, 19121917.
4. Choi, H.J., Han, S.W., Lee, S.J., Kim, K., J. Colloid Interf. Sci., 2003, 264, 458–66.
5. Shrivastava, S., Bera, T., Roy, A., Singh, G., Ramachandrarao, P., Dash, D., Nanotechnology, 2007, 18, 225103.1-9.
6. Martinez-Gutierrez, F., Olive, P. L., Banuelos, A., Orrantia, E., Nino, N., Sanchez, E. M., Ruiz, F., Bach, H., Av-Gay, Y., Nanomedicine: Nanotechnology, Biology, and Medicine, 2010, 6, 681688.
7. Dickert, F. L., Hayden, O., Anal. Chem. 2002, 74, 13021306.
8. Cohen, T., Starosvetsky, J., Cheruti, U., Armon, R., Int. J. of Mol. Sci. 2010, 11, 12361252.
9. Harvey, S., Mong, G., Ozanich, R., McLean, J., Goodwin, S., Valentine, N., Fredrickson, J., Anal. and Bioanal. Chem., 2006, 386, 211219.
10. Weinzierl, D., Lind, A., Kunz, W., Crystal Growth & Design, 2009, 9, 23182323.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

MRS Online Proceedings Library (OPL)
  • ISSN: -
  • EISSN: 1946-4274
  • URL: /core/journals/mrs-online-proceedings-library-archive
Please enter your name
Please enter a valid email address
Who would you like to send this to? *



Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed