Hostname: page-component-8448b6f56d-wq2xx Total loading time: 0 Render date: 2024-04-25T03:47:43.910Z Has data issue: false hasContentIssue false
  • English
  • Français

Nanoporous Alumina Coatings for Medical Implants and Stents - Radiotherapy, Drug Delivery, Biological Compatibility

Published online by Cambridge University Press:  21 February 2011

T. Sawitowski ,
W. Brandau ,
A. Fischer ,
A. Heilmann  and
G. Schmid
T. Sawitowski
Affiliation:
Institut für Werkstofftechnik, University of Essen, Universitätsstr. 5-7, 45130 Essen, Germany
W. Brandau
Affiliation:
Institut für Nuklearchemie und Radiopharmacie, University of Essen, 45122 Essen, Germany
A. Fischer
Affiliation:
Institut für Anorganische Chemie, University of Essen, Universitätsstr. 5-7, 45130 Essen, Germany Institut für Werkstofftechnik, University of Essen, Universitätsstr. 5-7, 45130 Essen, Germany
A. Heilmann
Affiliation:
Fraunhofer Institut für Werkstoffmechanik, Heideallee 19, D-06210 Halle, Germany
Get access

Abstract

The body implant interaction is strongly affected by the implant surface structure and chemistry [1,2]. Thus by applying a nanoporous coating to metallic implants the implant surface can be adjusted to different needs. Compared to biological molecules the size of the pores is so small (between 5 nm and 250 nm) that the cellular response to this surface modification is not affected by the structure itself. Nevertheless by loading the pores with bioactive molecules it is possible to achieve a new kind of active implants surfaces for soft and hard tissue implants. With this coating it is possible to irreversibly bind radioactive isotopes like 99mTc, 186/188Re, 103Pd, and many more for local radiotherapy onto soft tissue implants like stents or seeds.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 581: Symposium F – Nanophase & Nanocomposite Materials II , 1999 , 523
Copyright
Copyright © Materials Research Society 2000

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

1. Curtis, Adam, Wilkinson, Chris, Topographical control of cells, Biomaterials, 1997, 18, pp. 1573–1583 Google Scholar
2. Brunette, D.M., The effect of Surface Topography on cell migration and Adhesion, in “Surface Characterization of Biomaterials”, edited by Ratner, B.D., 1988, pp. 203–21Google Scholar
3. Jacobs, J.J., Jermy, L., Urban, R.M., Corrosion of metal Orthopedic Implants. The Journal of Bone and Joint Surgery, 1998, Vol. 80–A, pp. 268–282 Google Scholar
4. Serruys, P.W., Carlier, S.G., The scope of the Problem of Vascular Restenosis, in “Vascular brachytherapy - new perspectives”, edited by Levendag, P.C., 1999, pp. 4–7 Google Scholar
5. Hehrlein, C, et al, Influence of surface texture and charge on the biocompatibility ofendovascular stents, Coron Artery Dis. 1995, 6, pp. 581–586.Google Scholar
6. Dries, W.J.F., Endovascular Brachytherapy: Physics and Equipment, in “Vascular brachytherapy - new perspectives”, edited by Levendag, P.C., 1999, pp.22–25 Google Scholar
7. Waksman, R., Clinical Trials for coronary artery disease using beta sources, in “Vascular brachytherapy - new perspectives”, edited by Levendag, P.C., 1999, pp.31–36 Google Scholar
8. Quast, U., Definition and determination of the relevant parameters of vascular brachytherapy, in “Vascular brachytherapy - new perspectives”, edited by Levendag, P.C., 1999, pp. 51–74 Google Scholar
9. Sawitowski, T., Neue Nanokomposite - Goldcluster, Goldkolloide und Silizium in Aluminiumoxidmembranen - Struktur und Eigenschaften, Thesis, 1999 Google Scholar
10. Fischer, A., Brandau, W., Sawitowski, T., Schmid, G., German Patent Application No. 198 55 421.4, Radioactive Implants, (November 1998)Google Scholar
11. Fischer, A., Brandau, W., Sawitowski, T., Schmid, G., German Patent Application No. 199 10 188.4, Local Drug Delivery - 1, (March 1999)Google Scholar
12. Fischer, A., Brandau, W., Sawitowski, T., Schmid, G., German Patent Application No. 199 48 783.9, Local Drug Delivery - 2, (August 1999)Google Scholar