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    Brüggemann, Dorothea 2013. Nanoporous Aluminium Oxide Membranes as Cell Interfaces. Journal of Nanomaterials, Vol. 2013, p. 1.

    Friedmann, Andrea Hoess, Andreas Cismak, Andreas and Heilmann, Andreas 2011. Investigation of cell–substrate interactions by focused ion beam preparation and scanning electron microscopy. Acta Biomaterialia, Vol. 7, Issue. 6, p. 2499.

  • MRS Proceedings, Volume 1093
  • January 2008, 1093-CC04-16

Production of Highly Ordered Nanoporous Alumina and its Application in Cell Cultivation

  • Andreas Hoess (a1), Andrea Staeudte (a2), Annika Thormann (a3), Martin Steinhart (a4) and Andreas Heilmann (a5)
  • DOI:
  • Published online: 01 February 2011

Nanoporous alumina membranes were utilized as cell culture substrates. Two different anodization processes were applied in order to obtain highly ordered, self-supporting nanoporous alumina membranes. The resulting membranes exhibit uniform nanopores with constant diameters having aspect ratios (pore depth:pore diameter) larger than 1000. Tentative experiments evaluating the cellular interaction of a hepatoma cell line (HepG2) with the nanoporous alumina membranes will be described. Furthermore, cell proliferation as well as the adhesion behavior of the cells on the porous substrates was investigated. Scanning electron microscopy (SEM) and focused ion beam (FIB) technology were applied to examine the cell morphology. The experiments revealed that the nanoporous membranes can be used as cell culture substrates and that they have no adverse effects on cell proliferation and cell viability. Besides, cells on membranes with pore diameters larger than 200 nm developed small cell extensions (filopodia) which penetrated into the nanopores.

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