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Protein Assembly Through Site-specific Interactions with Gold Nanoparticles

  • Minghui Hu (a1), Luping Qian (a2), Raymond P Briñas (a3), Elena S Lymar (a4) and James F Hainfeld (a5)...

A universal method is described to design and construct protein-nanoparticle assemblies controlled by nanoparticle functionality, and placement of genetic tag into proteins. Well-defined binding complexes of nanoparticles and two proteins, the adenovirus serotype 12 knob and the mycobacterium tuberculosis 20S proteasome, were formed through site-specific binding between 6x-histidine tags in proteins and nickel-nitrilotriacetic acid functional groups on gold nanoparticles.

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MRS Online Proceedings Library (OPL)
  • ISSN: -
  • EISSN: 1946-4274
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