Skip to main content

Ruthenium(II)-nitrosyl polypyridinyl Complexes: from NO/ON Isomerization to NO delivery

  • Pascal G. Lacroix (a1) and Isabelle Malfant (a1)

Ruthenium-nitrosyl (RuII(NO)) complexes are stable in the dark, but exhibit a unique photoreactivity which can lead either to a solid state isomerization from RuII(NO) to RuII(ON), or to a nitric oxide (NO·) release in solution. From our recent discovery of a high yield of isomerization (> 92%) in [RuII(py)4Cl(NO)](PF6)2, we have developed a computational strategy aimed at designing switchable nonlinear optical (NLO) material with high contrast (large difference in the on / off NLO response) in the solid state. Our synthetic targets are terpyridine based RuII chromophores in which various substituents can be introduced to adjust the NLO response which, at best, should be vanishing in the off state. Alternatively, these complexes can undergo a photo-induced NO· release in solution, a possibility which becomes increasingly appealing in relation to the discovery of the numerous biological roles of NO·, in the context of the emergence of the photodynamic therapy. A promising fluorene-terpyridine RuII(NO) complex was investigated, which could find an additional interest in relation to its capability for releasing NO· by a two-photon absorption process.

Hide All
1. Molecular Switches, ed. B.L. Feringa (Wiley-VCH, Weinheim Germany, 2001).
2. Coe, B.J., Houbrechts, S., Asselberghs, I., Clays, K., and Persoons, A., Angew. Chem. Int. Ed. 38, 366 (1999).
3. Oudar, J.L., and Chemla, D.S., J. Chem. Phys. 66, 2664 (1977).
4. Coe, B.J., Acc. Chem. Res. 39, 383 (2006).
5. Champagne, B., Plaquet, A., Pozzo, J.-L., Rodriguez, V., and Castet, F., J. Am. Chem. Soc. 134, 8101 (2012).
6. Bonhommeau, S., Lacroix, P.G., Talaga, D., Bousseksou, A., Seredyuk, M., Fritsky, I.O., and Rodriguez, V., J. Phys. Chem. C 116, 11251 (2012)
7. Sliwa, M., Létard, S., Malfant, I., Nierlich, M., Lacroix, P.G., Asahi, T., Masuhara, H., Yu, P., and Nakatani, K., Chem. Mater. 17, 4727 (2005).
8. Hauser, U., Oestriech, V., and Rohrweck, H.D., Z. Physik A 280, 125 (1977).
9. Schaniel, D., Cormary, B., Malfant, I., Valade, L., Woike, T., Delley, B., Krämer, K. W., and Güdel, H.-U., Physical Chemistry, Chemical Physics, 9, 3717 (2007).
10. Cormary, B., Malfant, I., Valade, L., Buron-Le Cointe, M., Toupet, L., Todorova, T., Delley, B., Schaniel, D., Mockus, N., Woike, T., Fejfavora, K., Petricek, V., and Dusek, M., Acta Cryst., B65, 612 (2009).
11. Cormary, B., Ladeira, S., Jacob, K., Lacroix, P.G., Woike, T., Schaniel, D., and Malfant, I., Inorg. Chem. 51, 7492 (2012).
12. Malfant, I., and Cormary, B., CNRS Patent WO 2013/083920 A1, (2013).
13. Akl, J., Billot, Ch., Lacroix, P.G., Sasaki, I., Mallet-Ladeira, S., Malfant, I., Arcos-Ramos, R., Romero, M., and Farfan, N., New J. Chem. 37, 3518 (2013).
14. Akl, J., Sasaki, I, Lacroix, P.G., Malfant, I., Mallet-Ladeira, S., Vicendo, P., Farfán, N., and Santillan, R., Dalton Trans. 45, 12721 (2014).
15. Alary, F., and Heuly, J.L., unpublished results .
16. Lacroix, P.G., Eur. J. Inorg. Chem. 2001, 339.
17. Nitric Oxide and cancer : Prognosis, Prevention and Therapy, ed. B. Bonavida, Springer, 2010.
18. Ford, PC., Nitric Oxide 34, 56 (2013).
19. Pawlicki, M., Collins, H.A., Denning, R.G. and Anderson, H.L., Angew. Chem. Int. Ed. 48, 3244 (2009).
20. Blanchard-Desce, M., unpublished results .
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

MRS Online Proceedings Library (OPL)
  • ISSN: -
  • EISSN: 1946-4274
  • URL: /core/journals/mrs-online-proceedings-library-archive
Please enter your name
Please enter a valid email address
Who would you like to send this to? *



Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed