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The Scissors Model of Microcrack Detection in Bone: Work in Progress

  • David Taylor (a1), Lauren Mulcahy (a2), Gerardo Presbitero (a3), Pietro Tisbo (a4), Clodagh Dooley (a5), Garry Duffy (a6) and Thomas Clive Lee (a7)...

We have proposed a new model for microcrack detection by osteocytes in bone. According to this model, cell signalling is initiated by the cutting of cellular processes which span the crack. We show that shear displacements of the crack faces are needed to rupture these processes, in an action similar to that of a pair of scissors. Current work involves a combination of cell biology experiments, theoretical and experimental fracture mechanics and system modelling using control theory approaches. The approach will be useful for understanding effects of extreme loading, aging, disease states and drug treatments on bone damage and repair; the present paper presents recent results from experiments and simulations as part of current, ongoing research.

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1 D. Taylor , J. G. Hazenberg and T. C. Lee The cellular transducer in damagestimulated bone remodelling: A theoretical investigation using fracture mechanics,” Journal of Theoretical Biology, Vol. 225, No. 1, 2003, pp. 6575.

2 J. G. Hazenberg M. Freeley E. Foran T. C. Lee and D. Taylor Microdamage: a cell transducing mechanism based on ruptured osteocyte processes,” Journal of Biomechanics, Vol. 39, 2006, 20962103.

3 J. G. Hazenberg D. Taylor and T. C. Lee The role of osteocytes in functional bone adaptation,” BoneKey Osteovision, Vol. 3, 2006, pp. 1016.

4 J. G. Hazenberg D. Taylor and T. C. Lee The role of osteocytes in preventing osteoporotic fractures,” Osteoporosis International, Vol. 18, 2007, pp. 18.

6 D. Taylor and J. H. Kuiper The prediction of stress fractures using a ‘stressed volume’ concept,” Journal of Orthopaedic Research, Vol. 19, No. 5, 2001, pp. 919926.

7 D. Taylor Scaling effects in the fatigue strength of bones from different animals,” Journal of Theoretical Biology, Vol. 206, No. 2, 2000, pp. 299306.

8 D. Taylor Fatigue of bone and bones: An analysis based on stressed volume,” Journal of Orthopaedic Research, Vol. 16, No. 2, 1998, pp. 163169.

9 D. Taylor E. Casolari and C. Bignardi Predicting stress fractures using a probabilistic model of damage, repair and adaptation,” Journal of Orthopaedic Research, Vol. 22, 2004, pp. 487494.

10 W. B. Edwards D. Taylor T. J. Rudolphi J. C. Gillette and T. R. Derrick Effects of stride length and running mileage on a probabilistic stress fracture model,” Medicine and Science in Sports and Exercise, Vol. 41, No. 12, 2009, pp. 21772184.

12 R. T. Whalen D. R. Carter and C. R. Steele Influence of physical activity on the regulation of bone density,” Journal of Biomechanics, Vol. 21, No. 10, 1988, pp. 825837.

14 D. Taylor and T. C. Lee Microdamage and mechanical behaviour: Predicting failure and remodelling in compact bone,” Journal of Anatomy, Vol. 203, No. 2, 2003, pp. 203211.

15 D. Taylor and T. C. Lee A crack growth model for the simulation of fatigue in bone,” International Journal of Fatigue, Vol. 25, No. 5, 2003, pp. 387395.

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MRS Online Proceedings Library (OPL)
  • ISSN: -
  • EISSN: 1946-4274
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