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Silicon Nanotechnology for Biofiltration and Immunoisolated Cell Xenografts

Published online by Cambridge University Press:  15 February 2011

M. Ferrari ,
IW. Chu ,
IT. Desai ,
D. Hansford ,
G. Mazzoni ,
T. Huen  and
M. Zhang
M. Ferrari
Affiliation:
Biomedical Microdevices Workshop, University of California, Berkeley, CA 94720
IW. Chu
Affiliation:
Biomedical Microdevices Workshop, University of California, Berkeley, CA 94720
IT. Desai
Affiliation:
Biomedical Microdevices Workshop, University of California, Berkeley, CA 94720
D. Hansford
Affiliation:
Biomedical Microdevices Workshop, University of California, Berkeley, CA 94720
G. Mazzoni
Affiliation:
Microsurgical Institute, Mercy Hospital, San Diego, CA 92103
T. Huen
Affiliation:
Biomedical Microdevices Workshop, University of California, Berkeley, CA 94720
M. Zhang
Affiliation:
Biomedical Microdevices Workshop, University of California, Berkeley, CA 94720
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Abstract

Silicon-based clean-room technology is employed for the microfabrication of a particle filter with uniform pore dimensions in the 20-40-nm range. Surface and bulk micromachining are integrated in the fabrication process, resulting in a filtering membrane with large active area, flow rate and resistance to pressure. The microfabricated membrane is especially suitable for biofluid purification, including viral elimination. The nanofilter is a technological precursor for a microfabricated, silicon-based capsule to be employed in the reaction-free xenotransplantation of cells. Results are presented below that address the issue of biocompatibility of the microfabricated capsule components and materials.

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References

[1] See e.g.Microfabrication Technology for Research and Diagnostics, San Francisco, CA. (Cambridge Healthtech Institute. MA, 1995).Google Scholar
[2] Wyatt, D., Keathley, J., Williams, C., and Broce, R., BioPharm, June (1993) p. 34–40.Google Scholar
[3] Lanza, R. and Chick, W., Scientific American Science & Medicine, vol.2, n.4, (1995) p. 16.Google Scholar
[4] Norden, G., Sensors and Actuators, A21–A23, (1990) p.904,.Google Scholar
[5] Chu, W. and Ferrari, M., “Microfabricated Particle Filter with Anisotropically Etched Mnoncrystalline Support”;, University of California, Case#B95–033, 1994 patent pending.Google Scholar
[6] Chu, W. and Ferrari, M., “Silicon nanofilter with absolute pore size and high mechanical strength”, Microrobotics and Micromechanical Systems 1995, SPIE Proceedings Vol.2593.Google Scholar
[7] Black, J., Biological Performance of Materials: Fundamentals of Biocompatibility. (Marcel Dekker, Inc. New York, 1992).Google Scholar