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Simulation of the Mechanical Behavior of White Matter Using aMicromechanics Finite Element Method

Published online by Cambridge University Press:  21 March 2011

Yi Pan ,
Assimina A. Pelegri  and
David I. Shreiber
Yi Pan
Affiliation:
Department of Mechanical and Aerospace Engineering, Rutgers, the State University of New Jersey, 98 Brett Rd., Piscataway, NJ 08854, U.S.A.
Assimina A. Pelegri
Affiliation:
Department of Mechanical and Aerospace Engineering, Rutgers, the State University of New Jersey, 98 Brett Rd., Piscataway, NJ 08854, U.S.A.
David I. Shreiber
Affiliation:
Department of Biomedical Engineering, Rutgers, the State University of New Jersey, 599 Taylor Rd., Piscataway, NJ 08854, U.S.A.
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Abstract

The atypical mechanical behavior of white matter and its influence on themechanical properties of brain tissue necessitate adoption of a mutli-scalemodel of white matter for accurate computational analysis. Herein, wepresent a micromechanical analysis coupled with finite elements into abiomechanical interacting model of white matter. A representation of thewhite matter of central nervous system is identified and its microstructureis generated. The geometric descriptions of the axon and the surroundingmatrix are obtained from neurofilament immunohistochemistry images.Consecutively, linear elastic material constitutive models are applied todescribe the behavior of axons and their surrounding matrix subjected tosmall deformations. This model facilitates determination of the tissue’sstress and strain fields, and enables an understanding of the effects ofaxon undulation on local fields. The fundamental nature of the model enablesfuture scale-up for structural tissue analysis and predictions of axondamage at the microscale.

Keywords

tissuecompositebiological

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References

REFERENCES

[1] Margulies, S.S., Meaney, D.F., Bilston, L.E., Thibault, L.E., Campeau, N.G., and Riederer, S.J., in Proceedings of International IRCOBI Conference on the Biomechanics of Impacts, Verona, Italy, 1992.Google Scholar
[2] Gennarelli, T.A., Thibault, L.E., Tipperman, R., Tomei, G., Sergot, R., Brown, M., Maxwell, W.L., Graham, D.I., Adams, J.H., Irvine, A., Gennarelli, L.M., Duhaime, A.C., Boock, R., and Greenberg, J., Journal of Neurosurgery 71, 244 (1987).Google Scholar
[3] Voo, L., Kumaresan, S., Pintar, F., Yoganandan, N., and Sances, A., Medical and Biological Engineering and Computing 34, 375 (1996).Google Scholar
[4] Bain, A.C. and Meaney, D.F., Journal of Biomechanical Engineering 122, 615 (2000).Google Scholar
[5] Prange, M.T. and Margulies, S.S., Journal of Biomechanical Engineering 124, 244 (2002).Google Scholar
[6] Pintar, F.A., Kumaresan, S., Yoganandan, N., Yang, A., Stemper, B., and Gennarelli, T.A., Biomed Sci Instrum, 429 (2001).Google Scholar
[7] Maikos, J.T., Qian, Z., Metaxas, D., and Shreiber, D.I., Journal of Neurotrauma 25, 795 (2008).Google Scholar
[8] Zhang, L., Yang, K.H., and King, A.I., Journal of Biomechanical Engineering 126, 226 (2004).Google Scholar
[9] Zhu, Q., Prange, M., and Margulies, S., Developmental Neuroscience 28, 388 (2006).Google Scholar
[10] El Sayed, T., Mota, A., Fraternali, F., and Ortiz, M., Computer Methods in Applied Mechanics and Engineering 197, 4692 (2008).Google Scholar
[11] Hao, H. and Shreiber, D.I., Journal of Biomechanical Engineering 129, 511 (2007).Google Scholar
[12] Shreiber, D.I., Hao, H., and Elias, R.A., Biomechanics and Modeling in Mechanobiology 8, 311 (2009).Google Scholar
[13] Karami, G., Grundman, N., Abolfathi, N., Naik, A., and Ziejewski, M., Journal of the Mechanical Behavior of Biomedical Materials 2, 243 (2009).Google Scholar
[14] Bain, A.C., Shreiber, D.I., and Meaney, D.F., Transactions of the ASME 125, 798 (2003).Google Scholar
[15] Bernal, R., Pullarkat, P.A., and Melo, F., Physical Review Letters 99, 018301 (2007).Google Scholar
[16] Pan, Y., Iorga, L., and Pelegri, A.A., Composites Science and Technology 68, 2792 (2008).Google Scholar