Hostname: page-component-8448b6f56d-qsmjn Total loading time: 0 Render date: 2024-04-24T23:51:06.977Z Has data issue: false hasContentIssue false
  • English
  • Français

Synthesis of Fe3O4/ZnO Core-shell Nanoparticles for Photodynamic Therapy Applications

Published online by Cambridge University Press:  01 February 2011

Juan C. Beltran Huarac ,
Surinder P. Singh ,
Maharaj S. Tomar ,
Sandra Peňa ,
Luis Rivera  and
Oscar Perales-Perez
Juan C. Beltran Huarac
Affiliation:
juan.beltran1@upr.edu, University of Puerto Rico, Mayaguez, Physics, Mayaguez, Puerto Rico
Surinder P. Singh
Affiliation:
surinder.singh@uprm.edu, University of Puerto Rico, Mayaguez, Engineering Science & Materials, Mayaguez, Puerto Rico
Maharaj S. Tomar
Affiliation:
maharaj.tomar@upr.edu, University of Puerto Rico, Mayaguez, Physics, Mayaguez, Puerto Rico
Sandra Peňa
Affiliation:
sandraluengas@yahoo.es, University of Puerto Rico, Mayaguez, Chemistry, Mayaguez, Puerto Rico
Luis Rivera
Affiliation:
luis.upr@gmail.com, University of Puerto Rico, Mayaguez, Chemistry, Mayaguez, Puerto Rico
Oscar Perales-Perez
Affiliation:
operalesperez@yahoo.com, University of Puerto Rico, Mayaguez, Engineering Science & Materials, Mayaguez, Puerto Rico
Get access

Abstract

The use of nanoparticles as carriers of photosensitizer (PS) molecules for photodynamic therapy (PDT) has attracted much interest on core-shell nanosize structures. Herein, we used a simple aqueous solution method to synthesize Fe3O4/ZnO core-shell nanoparticles. X-ray diffraction (XRD) analyses showed the presence of well defined peaks corresponding to Fe3O4 and ZnO in as-synthesized nanocrystals. Vibrating sample magnetometer (VSM) measurements showed that these nanoparticles exhibited superparamagnetic behavior of the core with no coercivity nor remanence. X-ray photoelectron spectroscopy (XPS) analyses revealed the presence of Zn1/2 and Zn3/2 species on the surface of nanocrystals. Photoluminescence measurements showed excitonic emission of ZnO co-existing with a weak and broad defect- related green emission at room temperature. The generation of singlet oxygen was monitored via the photooxidation of diphenyl-1,3-isobenzofuran (DPBF) with different light sources, followed by absorption spectroscopy at 409 nm. The capability of synthesized nanoparticles to generate singlet oxygen has also been verified.

Keywords

core/shellmagneticbiomedical
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1257: Symposium O – Multifunctional Nanoparticle Systems-Coupled Behavior and Applications , 2010 , 1257-O06-04
Copyright
Copyright © Materials Research Society 2010

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

[1] Jun, Y., Choi, J., Cheon, J., Chem. Commun. (2007) 1203–1214.Google Scholar
[2] Joshi, P., Chakraborti, S., Chakrabarti, P., Haranath, D., Shanker, V., Ansari, Z. A., Singh, Surinder P., Gupta, V., J. Nanoscience and Nanotechnology (2009) 9:6427–33.Google Scholar
[3] Lin, C., Li, Y., Yu, M., Yang, P., Lin, J., Adv. Funct. Mater. (2007) 17:1459.Google Scholar
[4] Wang, K., Tan, W., He, X., Proceedings of the 2005 IEEE, Engineering in Medicine and Biology 27th Annual Conference, Shanghai, China, September 1–4.Google Scholar
[5] Hong, R.Y., Zhang, S.Z., Di, G.Q., Li, H.Z., Zheng, Y., Ding, J., Wei, D.G., Mat. Res. Bull. (2008) 43:2457–2468.Google Scholar
[6] K, Yi D.., T, Selvan S.., S, Lee S.., C, Papaefthymiou G.., Kundaliya, D., Y, Ying J.., J. Am. Chem. Soc. (2005)127:4990–1.Google Scholar
[7] S, Wang D.., He, J., Rosenzweig, N., Rosenzweig, Z., Nano Lett. (2004) 4:409–13.Google Scholar
[8] Gu, H., Zheng, R., Zhang, X., Xu, B., J. Am. Chem. Soc. (2004) 126:5664–5.Google Scholar
[9] N, Zare R.., H, Spencer B.., S, Springer D.., P, Jacobson M.., “Laser Experiments for beginners”, University Science Books: Sausalito CA., 1995, page 196.Google Scholar
[10] Kim, K. D., Kim, S. S., Choa, Y-H., Kim, H. T., J. Ind. Eng. Chem., (2007) 13:1137–1141.Google Scholar
[11] Liu, B., Wang, D., Huang, W., Yu, M., Yao, A., Mat. Res. Bull. (2008) 43:2904–2911.Google Scholar
[12] Spanhel, L., Anderson, M., J. Am. Chem. Soc. (1991) 113:2826–2833.Google Scholar
[13] Bussian, D., Crooker, S., Ying, M., Brynda, M., Efros, A., Klimov, V., Nature Mater. (2009) 8, 35–40.Google Scholar
[14] Lee, C. Y., Tseng, T. Y., Li, S. Y., Lin, P., Tamkang J. Sci. Eng. (2003) 6(2):127–132.Google Scholar
[15] DeRosa, M., Crutchley, R, Coordination Chemistry Review. (2002) 234:351–377.Google Scholar