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Tissue Engineered Growth of New Cartilage in the Shape of a Human Ear Using Synthetic Polymers Seeded with Chondrocytes

  • Charles A. Vacanti (a1), Linda G. Cima (a2), Dianne Ratkowski (a3), Joseph Upton (a4) and Joseph P. Vacanti (a4)...

This report concerns the tissue-engineered growth of new cartilage in the shape of a human ear. Using synthetic biodegradable polyesters, a porous, three dimensional device in the shape of a human ear was fabricated. The polymer matrices were seeded with living chondrocytes isolated from a freshly sacrificed calf shoulder and implanted subcutaneously on the dorsum of athymic rats. This resulted in the formation of new cartilage in the shape of a human ear of approximately the same dimensions as the original implants. Histological analysis revealed the presence of mature cartilage in all specimens.

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MRS Online Proceedings Library (OPL)
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  • EISSN: 1946-4274
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